Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents
In this paper some chalcones (C1-C8) are prepared based on the reaction of one mole of substituted acetophenone with one mole of substituted benzaldehydes in the presence of (40%) sodium hydroxide as a base. Pyrazolines (P1–P8) are prepared from the reaction of chalcones (C1-C8) with hydrazine hydra...
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University of Baghdad, College of Science for Women
2016-09-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2300 |
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| author | Baghdad Science Journal |
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| description | In this paper some chalcones (C1-C8) are prepared based on the reaction of one mole of substituted acetophenone with one mole of substituted benzaldehydes in the presence of (40%) sodium hydroxide as a base. Pyrazolines (P1–P8) are prepared from the reaction of chalcones (C1-C8) with hydrazine hydrate.
Isoxazoline (I1-I8) is prepared from the reaction of chalcones (C1-C8) with hydroxyl amine hydrochloride in the presence of (10%) sodium hydroxide as a base. These compounds are characterized by using various physical and spectral methods. The compounds are screened for their in vitro antibacterial activity using gram-positive bacteria and gram-negative bacteria. Several derivatives of pyrazolines and isoxazolines are produced well to moderate activities against number of bacteria. |
| format | Article |
| id | doaj-art-5348d55776044cd49918b63ddb8262df |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-5348d55776044cd49918b63ddb8262df2025-08-20T03:14:45ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862016-09-0113310.21123/bsj.13.3.568-577Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial AgentsBaghdad Science JournalIn this paper some chalcones (C1-C8) are prepared based on the reaction of one mole of substituted acetophenone with one mole of substituted benzaldehydes in the presence of (40%) sodium hydroxide as a base. Pyrazolines (P1–P8) are prepared from the reaction of chalcones (C1-C8) with hydrazine hydrate. Isoxazoline (I1-I8) is prepared from the reaction of chalcones (C1-C8) with hydroxyl amine hydrochloride in the presence of (10%) sodium hydroxide as a base. These compounds are characterized by using various physical and spectral methods. The compounds are screened for their in vitro antibacterial activity using gram-positive bacteria and gram-negative bacteria. Several derivatives of pyrazolines and isoxazolines are produced well to moderate activities against number of bacteria.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2300"Chalcones, Pyrazolines, Isoxazolines, Antibacterial" |
| spellingShingle | Baghdad Science Journal Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents مجلة بغداد للعلوم "Chalcones, Pyrazolines, Isoxazolines, Antibacterial" |
| title | Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents |
| title_full | Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents |
| title_fullStr | Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents |
| title_full_unstemmed | Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents |
| title_short | Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents |
| title_sort | synthesis and characterization of some new pyrazoline and isoxazoline derivatives as antibacterial agents |
| topic | "Chalcones, Pyrazolines, Isoxazolines, Antibacterial" |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2300 |
| work_keys_str_mv | AT baghdadsciencejournal synthesisandcharacterizationofsomenewpyrazolineandisoxazolinederivativesasantibacterialagents |