The Occurrence of Richter’s Syndrome during Treatment with Obinutuzumab and Chlorambucil
Chronic lymphocytic leukaemia is a slow-growing leukaemia of developing B-lymphocytes, which may transform to an aggressive lymphoma known as Richter’s syndrome. While Richter’s syndrome can present in untreated or relapsed-refractory cases, it may occur upon the commencement of less intensity treat...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2020/8363427 |
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| _version_ | 1850224757061976064 |
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| author | Teng Fong Ng Benedict Carnley Celia Green Dominic Spagnolo Michael F. Leahy |
| author_facet | Teng Fong Ng Benedict Carnley Celia Green Dominic Spagnolo Michael F. Leahy |
| author_sort | Teng Fong Ng |
| collection | DOAJ |
| description | Chronic lymphocytic leukaemia is a slow-growing leukaemia of developing B-lymphocytes, which may transform to an aggressive lymphoma known as Richter’s syndrome. While Richter’s syndrome can present in untreated or relapsed-refractory cases, it may occur upon the commencement of less intensity treatment regimens. We present a case of Richter’s syndrome following treatment with chlorambucil and obinutuzumab and review of available literature on the topic. |
| format | Article |
| id | doaj-art-53449e97e71f4e4095d8a0989a241e5e |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-53449e97e71f4e4095d8a0989a241e5e2025-08-20T02:05:32ZengWileyCase Reports in Hematology2090-65602090-65792020-01-01202010.1155/2020/83634278363427The Occurrence of Richter’s Syndrome during Treatment with Obinutuzumab and ChlorambucilTeng Fong Ng0Benedict Carnley1Celia Green2Dominic Spagnolo3Michael F. Leahy4Royal Perth Hospital, Perth, WA, AustraliaRoyal Perth Hospital, Perth, WA, AustraliaPathWest Laboratory Medicine, Perth, WA, AustraliaPathWest Laboratory Medicine, Perth, WA, AustraliaRoyal Perth Hospital, Perth, WA, AustraliaChronic lymphocytic leukaemia is a slow-growing leukaemia of developing B-lymphocytes, which may transform to an aggressive lymphoma known as Richter’s syndrome. While Richter’s syndrome can present in untreated or relapsed-refractory cases, it may occur upon the commencement of less intensity treatment regimens. We present a case of Richter’s syndrome following treatment with chlorambucil and obinutuzumab and review of available literature on the topic.http://dx.doi.org/10.1155/2020/8363427 |
| spellingShingle | Teng Fong Ng Benedict Carnley Celia Green Dominic Spagnolo Michael F. Leahy The Occurrence of Richter’s Syndrome during Treatment with Obinutuzumab and Chlorambucil Case Reports in Hematology |
| title | The Occurrence of Richter’s Syndrome during Treatment with Obinutuzumab and Chlorambucil |
| title_full | The Occurrence of Richter’s Syndrome during Treatment with Obinutuzumab and Chlorambucil |
| title_fullStr | The Occurrence of Richter’s Syndrome during Treatment with Obinutuzumab and Chlorambucil |
| title_full_unstemmed | The Occurrence of Richter’s Syndrome during Treatment with Obinutuzumab and Chlorambucil |
| title_short | The Occurrence of Richter’s Syndrome during Treatment with Obinutuzumab and Chlorambucil |
| title_sort | occurrence of richter s syndrome during treatment with obinutuzumab and chlorambucil |
| url | http://dx.doi.org/10.1155/2020/8363427 |
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