Case Report: Pulmonary and gastrointestinal involvement in a rare case of Waldenström’s Macroglobulinemia in French Guiana
BackgroundWaldenström’s Macroglobulinemia (WM) is a rare lymphoproliferative disorder characterized by the proliferation of lymphoplasmacytic cells producing monoclonal immunoglobulin M (IgM). Extra-hematopoietic involvement, although rare, can affect the gastrointestinal tract in approximately 4% o...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1551600/full |
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| author | Houari Aissaoui Dana Gaudard Ghazi Hadj Amara Alolia Aboikoni Yanna Lingibe Dominique Louvel |
| author_facet | Houari Aissaoui Dana Gaudard Ghazi Hadj Amara Alolia Aboikoni Yanna Lingibe Dominique Louvel |
| author_sort | Houari Aissaoui |
| collection | DOAJ |
| description | BackgroundWaldenström’s Macroglobulinemia (WM) is a rare lymphoproliferative disorder characterized by the proliferation of lymphoplasmacytic cells producing monoclonal immunoglobulin M (IgM). Extra-hematopoietic involvement, although rare, can affect the gastrointestinal tract in approximately 4% of cases and the lungs in 3–5% of cases. This case highlights the diversity of extramedullary manifestations in WM and underscores the importance of performing pulmonary and gastrointestinal endoscopies with systematic biopsies for optimal disease management.Case presentationWe report the case of a 60-year-old Haitian man diagnosed with WM in January 2023 following an episode of acute respiratory failure. Biopsies revealed lymphoplasmacytic infiltration in both the bronchial and gastrointestinal mucosa. Biopsies revealed lymphoplasmacytic infiltration in both the bronchial and gastrointestinal mucosa, despite normal macroscopic findings during gastrointestinal endoscopy.ConclusionThis case emphasizes the importance of systematic biopsies during endoscopic examinations, even in the absence of visible lesions, to detect lymphoplasmacytic infiltration in WM. These findings could help in changing the approach to disease management and improving patient outcomes. |
| format | Article |
| id | doaj-art-53409eab323a4fd9a7c8d47a2c37ceb4 |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-53409eab323a4fd9a7c8d47a2c37ceb42025-08-20T02:14:54ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-05-011210.3389/fmed.2025.15516001551600Case Report: Pulmonary and gastrointestinal involvement in a rare case of Waldenström’s Macroglobulinemia in French GuianaHouari Aissaoui0Dana Gaudard1Ghazi Hadj Amara2Alolia Aboikoni3Yanna Lingibe4Dominique Louvel5Department of Medicine B, Cayenne Hospital Center - Andrée Rosemon, Cayenne, FranceDepartment of Internal Medicine, Cayenne Hospital Centre, Cayenne, FranceDepartment of Pathology, Cayenne Hospital Centre, Cayenne, FranceDepartment of Medicine B, Cayenne Hospital Center - Andrée Rosemon, Cayenne, FranceDepartment of Medicine B, Cayenne Hospital Center - Andrée Rosemon, Cayenne, FranceDepartment of Medicine B, Cayenne Hospital Center - Andrée Rosemon, Cayenne, FranceBackgroundWaldenström’s Macroglobulinemia (WM) is a rare lymphoproliferative disorder characterized by the proliferation of lymphoplasmacytic cells producing monoclonal immunoglobulin M (IgM). Extra-hematopoietic involvement, although rare, can affect the gastrointestinal tract in approximately 4% of cases and the lungs in 3–5% of cases. This case highlights the diversity of extramedullary manifestations in WM and underscores the importance of performing pulmonary and gastrointestinal endoscopies with systematic biopsies for optimal disease management.Case presentationWe report the case of a 60-year-old Haitian man diagnosed with WM in January 2023 following an episode of acute respiratory failure. Biopsies revealed lymphoplasmacytic infiltration in both the bronchial and gastrointestinal mucosa. Biopsies revealed lymphoplasmacytic infiltration in both the bronchial and gastrointestinal mucosa, despite normal macroscopic findings during gastrointestinal endoscopy.ConclusionThis case emphasizes the importance of systematic biopsies during endoscopic examinations, even in the absence of visible lesions, to detect lymphoplasmacytic infiltration in WM. These findings could help in changing the approach to disease management and improving patient outcomes.https://www.frontiersin.org/articles/10.3389/fmed.2025.1551600/fullWaldenström’s Macroglobulinemiapulmonary and digestive endoscopyextra-hematopoietic involvementlymphoplasmacytic infiltrationsystematic biopsies |
| spellingShingle | Houari Aissaoui Dana Gaudard Ghazi Hadj Amara Alolia Aboikoni Yanna Lingibe Dominique Louvel Case Report: Pulmonary and gastrointestinal involvement in a rare case of Waldenström’s Macroglobulinemia in French Guiana Frontiers in Medicine Waldenström’s Macroglobulinemia pulmonary and digestive endoscopy extra-hematopoietic involvement lymphoplasmacytic infiltration systematic biopsies |
| title | Case Report: Pulmonary and gastrointestinal involvement in a rare case of Waldenström’s Macroglobulinemia in French Guiana |
| title_full | Case Report: Pulmonary and gastrointestinal involvement in a rare case of Waldenström’s Macroglobulinemia in French Guiana |
| title_fullStr | Case Report: Pulmonary and gastrointestinal involvement in a rare case of Waldenström’s Macroglobulinemia in French Guiana |
| title_full_unstemmed | Case Report: Pulmonary and gastrointestinal involvement in a rare case of Waldenström’s Macroglobulinemia in French Guiana |
| title_short | Case Report: Pulmonary and gastrointestinal involvement in a rare case of Waldenström’s Macroglobulinemia in French Guiana |
| title_sort | case report pulmonary and gastrointestinal involvement in a rare case of waldenstrom s macroglobulinemia in french guiana |
| topic | Waldenström’s Macroglobulinemia pulmonary and digestive endoscopy extra-hematopoietic involvement lymphoplasmacytic infiltration systematic biopsies |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1551600/full |
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