Single-cell and spatial transcriptomic analyses revealing tumor microenvironment remodeling after neoadjuvant chemoimmunotherapy in non-small cell lung cancer

Single-cell and spatial transcriptomic analyses revealing tumor microenvironment remodeling after neoadjuvant chemoimmunotherapy in non-small cell lung cancer

Abstract Non-small cell lung cancer (NSCLC) represents the most common pathological type of lung cancer, and the combination of neoadjuvant immunotherapy with chemotherapy has emerged as the first-line treatment for NSCLC. Nevertheless, the efficacy of this therapeutic approach remains variable. The...

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Bibliographic Details
Main Authors: Xiaolu Cui, Siyuan Liu, He Song, Jingjing Xu, Yanbin Sun
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Molecular Cancer
Subjects:
Non-small cell lung cancer
Single-cell RNA sequencing
Spatial transcriptome
Neoadjuvant chemoimmunotherapy
Tertiary lymphoid structures
Online Access:https://doi.org/10.1186/s12943-025-02287-w
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