Rewiring of SINE-MIR enhancer topology and Esrrb modulation in expanded and naive pluripotency

Rewiring of SINE-MIR enhancer topology and Esrrb modulation in expanded and naive pluripotency

Abstract Background The interplay between 3D genomic structure and transposable elements (TE) in regulating cell state-specific gene expression program is largely unknown. Here, we explore the utilization of TE-derived enhancers in naïve and expanded pluripotent states by integrative analysis of gen...

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Main Authors: Nadia Omega Cipta, Yingying Zeng, Ka Wai Wong, Zi Hao Zheng, Yao Yi, Tushar Warrier, Jian Zhou Teo, Jia Hao Jackie Teo, Yee Jiun Kok, Xuezhi Bi, Reshma Taneja, Derrick Sek Tong Ong, Jian Xu, Florent Ginhoux, Hu Li, Yih-Cherng Liou, Yuin-Han Loh
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Genome Biology
Subjects:
3D genome
Pluripotency
Transposable element
Mouse embryonic stem cells
Online Access:https://doi.org/10.1186/s13059-025-03577-8
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