Intentional heterogeneity in autologous cell-based gene therapies: strategic considerations for first-in-human trials

Intentional heterogeneity in autologous cell-based gene therapies: strategic considerations for first-in-human trials

Cell-based gene therapies, including chimeric antigen receptor-T, T-cell receptor-T, and tumor-infiltrating lymphocyte therapies, have transformed the treatment landscape for certain cancers, yet their efficacy in solid tumors remains limited. Next-generation therapies aim to overcome biological bar...

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Bibliographic Details
Main Authors: Antoni Ribas, Carl H June, Philip D Greenberg, Crystal L Mackall, Marcela V Maus, John E Connolly, Christopher R Cabanski, Ute Dugan, Mark D Stewart, Jeff D Allen, EnJun Yang, Alexander Marson
Format: Article
Language:English
Published: BMJ Publishing Group 2025-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/6/e011301.full
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