Determination of Chlorpromazine Using Molecular Imprinting Polymers in Different Sample Matrices
Antipsychotic drugs, including chlorpromazine, are frequently used to treat mental illnesses. However, prolonged exposure to even small amounts of the substance can accumulate and cause a potential human health risk. Thus, the selective and sensitive detection of these drugs is crucial. Molecularly...
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Department of Chemistry, Universitas Gadjah Mada
2024-12-01
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| Series: | Indonesian Journal of Chemistry |
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| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/94705 |
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| author | Eman Wajeh Ammen Yehya Kamal Al-Bayati |
| author_facet | Eman Wajeh Ammen Yehya Kamal Al-Bayati |
| author_sort | Eman Wajeh Ammen |
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| description | Antipsychotic drugs, including chlorpromazine, are frequently used to treat mental illnesses. However, prolonged exposure to even small amounts of the substance can accumulate and cause a potential human health risk. Thus, the selective and sensitive detection of these drugs is crucial. Molecularly imprinted polymers (MIPs) are receptors that are designed to have a highly specific molecular recognition ability, which is the primary and crucial function of receptors. The synthesis of chlorpromazine-imprinted polymers involves the polymerization of functional monomers and cross-linkers in the presence of chlorpromazine as a template, followed by the removal of the template to create cavities with complementary binding sites. Various strategies, including bulk polymerization, free radical polymerization surface imprinting, and nanoimprinting, have been employed to fabricate chlorpromazine-molecular imprinted polymers with high affinity and selectivity. Characterization techniques such as UV-vis spectroscopy, Fourier-transform infrared spectroscopy, and scanning electron microscopy are commonly employed to confirm the successful imprinting of chlorpromazine. The high selectivity of MIP toward templates enables them to be used in various applications like solid-phase extraction and chemical sensors, among others. The aim of this review is to present and highlight the various methods used to determine chlorpromazine based on molecular imprinting polymers in different samples. |
| format | Article |
| id | doaj-art-533459a8334a41faaa485829f07f0d96 |
| institution | Kabale University |
| issn | 1411-9420 2460-1578 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj-art-533459a8334a41faaa485829f07f0d962024-12-02T08:18:18ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782024-12-012461870188210.22146/ijc.9470536439Determination of Chlorpromazine Using Molecular Imprinting Polymers in Different Sample MatricesEman Wajeh Ammen0Yehya Kamal Al-Bayati1Department of Chemistry, College of Science, University of Baghdad, Baghdad 10071, Iraq; Scientific Research Commission, Ministry of Higher Education & Scientific Research,Baghdad 10070, IraqDepartment of Chemistry, College of Science, University of Baghdad, Baghdad 10071, IraqAntipsychotic drugs, including chlorpromazine, are frequently used to treat mental illnesses. However, prolonged exposure to even small amounts of the substance can accumulate and cause a potential human health risk. Thus, the selective and sensitive detection of these drugs is crucial. Molecularly imprinted polymers (MIPs) are receptors that are designed to have a highly specific molecular recognition ability, which is the primary and crucial function of receptors. The synthesis of chlorpromazine-imprinted polymers involves the polymerization of functional monomers and cross-linkers in the presence of chlorpromazine as a template, followed by the removal of the template to create cavities with complementary binding sites. Various strategies, including bulk polymerization, free radical polymerization surface imprinting, and nanoimprinting, have been employed to fabricate chlorpromazine-molecular imprinted polymers with high affinity and selectivity. Characterization techniques such as UV-vis spectroscopy, Fourier-transform infrared spectroscopy, and scanning electron microscopy are commonly employed to confirm the successful imprinting of chlorpromazine. The high selectivity of MIP toward templates enables them to be used in various applications like solid-phase extraction and chemical sensors, among others. The aim of this review is to present and highlight the various methods used to determine chlorpromazine based on molecular imprinting polymers in different samples.https://jurnal.ugm.ac.id/ijc/article/view/94705chlorpromazinemolecular imprinting polymersapplications |
| spellingShingle | Eman Wajeh Ammen Yehya Kamal Al-Bayati Determination of Chlorpromazine Using Molecular Imprinting Polymers in Different Sample Matrices Indonesian Journal of Chemistry chlorpromazine molecular imprinting polymers applications |
| title | Determination of Chlorpromazine Using Molecular Imprinting Polymers in Different Sample Matrices |
| title_full | Determination of Chlorpromazine Using Molecular Imprinting Polymers in Different Sample Matrices |
| title_fullStr | Determination of Chlorpromazine Using Molecular Imprinting Polymers in Different Sample Matrices |
| title_full_unstemmed | Determination of Chlorpromazine Using Molecular Imprinting Polymers in Different Sample Matrices |
| title_short | Determination of Chlorpromazine Using Molecular Imprinting Polymers in Different Sample Matrices |
| title_sort | determination of chlorpromazine using molecular imprinting polymers in different sample matrices |
| topic | chlorpromazine molecular imprinting polymers applications |
| url | https://jurnal.ugm.ac.id/ijc/article/view/94705 |
| work_keys_str_mv | AT emanwajehammen determinationofchlorpromazineusingmolecularimprintingpolymersindifferentsamplematrices AT yehyakamalalbayati determinationofchlorpromazineusingmolecularimprintingpolymersindifferentsamplematrices |