Lysine residue at position 22 of the AID protein regulates its class switch activity.

Lysine residue at position 22 of the AID protein regulates its class switch activity.

<h4>Background</h4>Activation induced deaminase (AID) mediates class switch recombination and somatic hypermutation of immunoglobulin (Ig) genes in germinal centre B cells. In order to regulate its specific activity and as a means to keep off-target mutations low, several mechanisms have...

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Bibliographic Details
Main Authors: Roland Geisberger, Michael Huemer, Franz J Gassner, Nadja Zaborsky, Alexander Egle, Richard Greil
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030667&type=printable
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