Inhibition of the complement component C5 and the Toll-like receptor molecule CD14 prevents systemic and local kidney inflammation in mice experiencing brain death

Inhibition of the complement component C5 and the Toll-like receptor molecule CD14 prevents systemic and local kidney inflammation in mice experiencing brain death

Abstract Brain death (BD) induces a systemic inflammation impairing donor organ quality. Complement and Toll-like receptors (TLRs), with the key co-receptor CD14 molecule, are key innate recognition immune systems. We hypothesized that dual inhibition of complement (C5) and TLRs (CD14) will prevent...

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Bibliographic Details
Main Authors: Tom E. Mollnes, Neeltina M. Jager, Petra J. Ottens, Camilla Schjalm, Zwanida J. Veldhuis, Henri G. D. Leuvenink, Søren E. Pischke
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Brain death
Donor
Inflammation
Complement
CD14
Kidney
Online Access:https://doi.org/10.1038/s41598-025-12071-x
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