The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer
Abstract Hormone receptor-positive breast cancers are a diverse group of tumours, with only some responding well to immunotherapy. Alternative combination strategies such as radiotherapy present an exciting opportunity to improve immunotherapy responses. We review an intriguing overlap between the i...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | npj Breast Cancer |
| Online Access: | https://doi.org/10.1038/s41523-025-00796-x |
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| _version_ | 1849342613498363904 |
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| author | Matthew Fenton Miki Yoneyama Erik Wennerberg Tom Lund Andrew Tutt Alan Melcher Sandra Demaria Navita Somaiah |
| author_facet | Matthew Fenton Miki Yoneyama Erik Wennerberg Tom Lund Andrew Tutt Alan Melcher Sandra Demaria Navita Somaiah |
| author_sort | Matthew Fenton |
| collection | DOAJ |
| description | Abstract Hormone receptor-positive breast cancers are a diverse group of tumours, with only some responding well to immunotherapy. Alternative combination strategies such as radiotherapy present an exciting opportunity to improve immunotherapy responses. We review an intriguing overlap between the impact of oestrogen signalling and radiation on multiple signalling pathways and immune cells that may be exploited for therapeutic gains in breast cancer. This is synthesised with the pre-clinical data and clinical trial landscape supporting the use of combined radiation and immunotherapy to derive insights for future neo-adjuvant trial design. |
| format | Article |
| id | doaj-art-53265644cc134f4ab871e8caa1876021 |
| institution | Kabale University |
| issn | 2374-4677 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Breast Cancer |
| spelling | doaj-art-53265644cc134f4ab871e8caa18760212025-08-20T03:43:20ZengNature Portfolionpj Breast Cancer2374-46772025-07-0111111510.1038/s41523-025-00796-xThe untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancerMatthew Fenton0Miki Yoneyama1Erik Wennerberg2Tom Lund3Andrew Tutt4Alan Melcher5Sandra Demaria6Navita Somaiah7Division of Radiotherapy and Imaging, Institute of Cancer ResearchDivision of Radiotherapy and Imaging, Institute of Cancer ResearchDivision of Radiotherapy and Imaging, Institute of Cancer ResearchRoyal Marsden NHS Foundation TrustThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchDivision of Radiotherapy and Imaging, Institute of Cancer ResearchWeill Cornell MedicineDivision of Radiotherapy and Imaging, Institute of Cancer ResearchAbstract Hormone receptor-positive breast cancers are a diverse group of tumours, with only some responding well to immunotherapy. Alternative combination strategies such as radiotherapy present an exciting opportunity to improve immunotherapy responses. We review an intriguing overlap between the impact of oestrogen signalling and radiation on multiple signalling pathways and immune cells that may be exploited for therapeutic gains in breast cancer. This is synthesised with the pre-clinical data and clinical trial landscape supporting the use of combined radiation and immunotherapy to derive insights for future neo-adjuvant trial design.https://doi.org/10.1038/s41523-025-00796-x |
| spellingShingle | Matthew Fenton Miki Yoneyama Erik Wennerberg Tom Lund Andrew Tutt Alan Melcher Sandra Demaria Navita Somaiah The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer npj Breast Cancer |
| title | The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer |
| title_full | The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer |
| title_fullStr | The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer |
| title_full_unstemmed | The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer |
| title_short | The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer |
| title_sort | untapped potential of radiation and immunotherapy for hormone receptor positive breast cancer |
| url | https://doi.org/10.1038/s41523-025-00796-x |
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