Targeting SOST using a small-molecule compound retards breast cancer bone metastasis

Targeting SOST using a small-molecule compound retards breast cancer bone metastasis

Abstract Background Breast cancer metastasis to the bone can be exacerbated by osteoporosis, is associated with poor long-term survival, and has limited therapeutic options. Sclerostin (SOST) is an endogenous inhibitor of bone formation, and an attractive target for treatment of osteoporosis. Howeve...

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Bibliographic Details
Main Authors: Lisha Sun, Yixiao Zhang, Guanglei Chen, Yaoting Ji, Qingtian Ma, Xinbo Qiao, Sijin Wu, Lin Zhou, Jiawen Bu, Xudong Zhu, Xiaoying Zhang, Xiaofan Jiang, Chao Liu, Xinnan Li, Yang Liu, Yongliang Yang, Caigang Liu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Molecular Cancer
Subjects:
SOST
Bone metastasis
Breast cancer
Small-molecule compound
Online Access:https://doi.org/10.1186/s12943-022-01697-4
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