Comparative assessment of <i>Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus rhamnosus</i> and <i>Saccharomyces boulardii</i> efficacy at diarrheal variant of irritable bowel syndrome
Aim of investigation. To estimate effect of probiotics on severity of clinical symptoms, presence of bacterial overgrowth syndrome (BOS) and quality of life at diarrheal variant of irritable bowel syndrome (IBS-D).Material and methods. In 47 patients with diagnosis of IBS-D, confirmed by conformity...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2015-05-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/998 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860192314392576 |
|---|---|
| author | V. T. Ivashkin O. M. Drapkina A. A. Sheptulin O. S. Shifrin Ye. A. Poluektova S. Yu. Kuchumova |
| author_facet | V. T. Ivashkin O. M. Drapkina A. A. Sheptulin O. S. Shifrin Ye. A. Poluektova S. Yu. Kuchumova |
| author_sort | V. T. Ivashkin |
| collection | DOAJ |
| description | Aim of investigation. To estimate effect of probiotics on severity of clinical symptoms, presence of bacterial overgrowth syndrome (BOS) and quality of life at diarrheal variant of irritable bowel syndrome (IBS-D).Material and methods. In 47 patients with diagnosis of IBS-D, confirmed by conformity of symptoms to Rome-III criteria and absence of organic diseases according to carried out investigation comparative analysis of effect of probiotics and placebo on development of main clinical symptoms, state of intestinal microflora and quality of life was applied. Efficacy of probiotics containing microorganisms Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus rhamnosus (Florasan-D); yeast Saccharomyces boulardii (Enterol) was studied. Overall 25 men (53,2 %) and 22 women (46,8 %) with mean age 33 year (31,5; 37,8) were investigated. Probiotics Florasan-D, Enterol and placebo were prescribed in a doze of 250 mg bid. Intensity of abdominal pain and meteorism was estimated by visual analog scale (VAS), consistency of stool – by Bristol stool form scale, defecation rate — by calculation of number of bowel movements during every week of treatment. Besides that presence of BOS was investigated by hydrogen breath test with lactulose, quality of a life was determined using The Short Form-36 (SF-36) questionnaire prior to treatment onset and its termination. Treatment lasted for 28 days.Results. In group of the patients who received Florasan-D and Enterol, in contrast to as placebo group improvement in relation to severity of main clinical symptoms was marked, quality of a life score increased. Besides that, according to hydrogen breath test with lactulose results on a background of Florasan-D it was possible to eliminate BOS in all patients. |
| format | Article |
| id | doaj-art-5316aece7deb411db4fcaebfd6ed0ec3 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2015-05-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-5316aece7deb411db4fcaebfd6ed0ec32025-02-10T16:14:33ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732015-05-012521021606Comparative assessment of <i>Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus rhamnosus</i> and <i>Saccharomyces boulardii</i> efficacy at diarrheal variant of irritable bowel syndromeV. T. Ivashkin0O. M. Drapkina1A. A. Sheptulin2O. S. Shifrin3Ye. A. Poluektova4S. Yu. Kuchumova5State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationAim of investigation. To estimate effect of probiotics on severity of clinical symptoms, presence of bacterial overgrowth syndrome (BOS) and quality of life at diarrheal variant of irritable bowel syndrome (IBS-D).Material and methods. In 47 patients with diagnosis of IBS-D, confirmed by conformity of symptoms to Rome-III criteria and absence of organic diseases according to carried out investigation comparative analysis of effect of probiotics and placebo on development of main clinical symptoms, state of intestinal microflora and quality of life was applied. Efficacy of probiotics containing microorganisms Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus rhamnosus (Florasan-D); yeast Saccharomyces boulardii (Enterol) was studied. Overall 25 men (53,2 %) and 22 women (46,8 %) with mean age 33 year (31,5; 37,8) were investigated. Probiotics Florasan-D, Enterol and placebo were prescribed in a doze of 250 mg bid. Intensity of abdominal pain and meteorism was estimated by visual analog scale (VAS), consistency of stool – by Bristol stool form scale, defecation rate — by calculation of number of bowel movements during every week of treatment. Besides that presence of BOS was investigated by hydrogen breath test with lactulose, quality of a life was determined using The Short Form-36 (SF-36) questionnaire prior to treatment onset and its termination. Treatment lasted for 28 days.Results. In group of the patients who received Florasan-D and Enterol, in contrast to as placebo group improvement in relation to severity of main clinical symptoms was marked, quality of a life score increased. Besides that, according to hydrogen breath test with lactulose results on a background of Florasan-D it was possible to eliminate BOS in all patients.https://www.gastro-j.ru/jour/article/view/998irritable bowel syndromeintestinal microbiomebacterial overgrowth syndromeprobioticsflorasan-denterol |
| spellingShingle | V. T. Ivashkin O. M. Drapkina A. A. Sheptulin O. S. Shifrin Ye. A. Poluektova S. Yu. Kuchumova Comparative assessment of <i>Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus rhamnosus</i> and <i>Saccharomyces boulardii</i> efficacy at diarrheal variant of irritable bowel syndrome Российский журнал гастроэнтерологии, гепатологии, колопроктологии irritable bowel syndrome intestinal microbiome bacterial overgrowth syndrome probiotics florasan-d enterol |
| title | Comparative assessment of <i>Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus rhamnosus</i> and <i>Saccharomyces boulardii</i> efficacy at diarrheal variant of irritable bowel syndrome |
| title_full | Comparative assessment of <i>Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus rhamnosus</i> and <i>Saccharomyces boulardii</i> efficacy at diarrheal variant of irritable bowel syndrome |
| title_fullStr | Comparative assessment of <i>Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus rhamnosus</i> and <i>Saccharomyces boulardii</i> efficacy at diarrheal variant of irritable bowel syndrome |
| title_full_unstemmed | Comparative assessment of <i>Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus rhamnosus</i> and <i>Saccharomyces boulardii</i> efficacy at diarrheal variant of irritable bowel syndrome |
| title_short | Comparative assessment of <i>Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus rhamnosus</i> and <i>Saccharomyces boulardii</i> efficacy at diarrheal variant of irritable bowel syndrome |
| title_sort | comparative assessment of i bifidobacterium bifidum bifidobacterium longum bifidobacterium infantis lactobacillus rhamnosus i and i saccharomyces boulardii i efficacy at diarrheal variant of irritable bowel syndrome |
| topic | irritable bowel syndrome intestinal microbiome bacterial overgrowth syndrome probiotics florasan-d enterol |
| url | https://www.gastro-j.ru/jour/article/view/998 |
| work_keys_str_mv | AT vtivashkin comparativeassessmentofibifidobacteriumbifidumbifidobacteriumlongumbifidobacteriuminfantislactobacillusrhamnosusiandisaccharomycesboulardiiiefficacyatdiarrhealvariantofirritablebowelsyndrome AT omdrapkina comparativeassessmentofibifidobacteriumbifidumbifidobacteriumlongumbifidobacteriuminfantislactobacillusrhamnosusiandisaccharomycesboulardiiiefficacyatdiarrhealvariantofirritablebowelsyndrome AT aasheptulin comparativeassessmentofibifidobacteriumbifidumbifidobacteriumlongumbifidobacteriuminfantislactobacillusrhamnosusiandisaccharomycesboulardiiiefficacyatdiarrhealvariantofirritablebowelsyndrome AT osshifrin comparativeassessmentofibifidobacteriumbifidumbifidobacteriumlongumbifidobacteriuminfantislactobacillusrhamnosusiandisaccharomycesboulardiiiefficacyatdiarrhealvariantofirritablebowelsyndrome AT yeapoluektova comparativeassessmentofibifidobacteriumbifidumbifidobacteriumlongumbifidobacteriuminfantislactobacillusrhamnosusiandisaccharomycesboulardiiiefficacyatdiarrhealvariantofirritablebowelsyndrome AT syukuchumova comparativeassessmentofibifidobacteriumbifidumbifidobacteriumlongumbifidobacteriuminfantislactobacillusrhamnosusiandisaccharomycesboulardiiiefficacyatdiarrhealvariantofirritablebowelsyndrome |