New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer
Prostate cancer is the most common cancer in men in the United States, and it is the second leading cause of cancer-related death in American men. The androgen receptor (AR), a receptor of nuclear family and a transcription factor, is the most important target in this disease. While most efforts in...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2011/918707 |
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| author | Abhijit M. Godbole Vincent C. O. Njar |
| author_facet | Abhijit M. Godbole Vincent C. O. Njar |
| author_sort | Abhijit M. Godbole |
| collection | DOAJ |
| description | Prostate cancer is the most common cancer in men in the United States, and it is the second leading cause of cancer-related death in American men. The androgen receptor (AR), a receptor of nuclear family and a transcription factor, is the most important target in this disease. While most efforts in the clinic are currently directed at lowering levels of androgens that activate AR, resistance to androgen deprivation eventually develops. Most prostate cancer deaths are attributable to this castration-resistant form of prostate cancer (CRPC). Recent work has shed light on the importance of epigenetic events including facilitation of AR signaling by histone-modifying enzymes, posttranslational modifications of AR such as sumoylation. Herein, we provide an overview of the structure of human AR and its key structural domains that can be used as targets to develop novel antiandrogens. We also summarize recent findings about the antiandrogens and the epigenetic factors that modulate the action of AR. |
| format | Article |
| id | doaj-art-530c30b310984ffb804aab3bd590137b |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-530c30b310984ffb804aab3bd590137b2025-02-03T01:24:35ZengWileyProstate Cancer2090-31112090-312X2011-01-01201110.1155/2011/918707918707New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate CancerAbhijit M. Godbole0Vincent C. O. Njar1Department of Pharmaceutical Sciences, Jefferson School of Pharmacy, Thomas Jefferson University, 130 South 9th Street, Edison Building, Suite 1510F, Philadelphia, PA 19107, USADepartment of Pharmaceutical Sciences, Jefferson School of Pharmacy, Thomas Jefferson University, 130 South 9th Street, Edison Building, Suite 1510F, Philadelphia, PA 19107, USAProstate cancer is the most common cancer in men in the United States, and it is the second leading cause of cancer-related death in American men. The androgen receptor (AR), a receptor of nuclear family and a transcription factor, is the most important target in this disease. While most efforts in the clinic are currently directed at lowering levels of androgens that activate AR, resistance to androgen deprivation eventually develops. Most prostate cancer deaths are attributable to this castration-resistant form of prostate cancer (CRPC). Recent work has shed light on the importance of epigenetic events including facilitation of AR signaling by histone-modifying enzymes, posttranslational modifications of AR such as sumoylation. Herein, we provide an overview of the structure of human AR and its key structural domains that can be used as targets to develop novel antiandrogens. We also summarize recent findings about the antiandrogens and the epigenetic factors that modulate the action of AR.http://dx.doi.org/10.1155/2011/918707 |
| spellingShingle | Abhijit M. Godbole Vincent C. O. Njar New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer Prostate Cancer |
| title | New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer |
| title_full | New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer |
| title_fullStr | New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer |
| title_full_unstemmed | New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer |
| title_short | New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer |
| title_sort | new insights into the androgen targeted therapies and epigenetic therapies in prostate cancer |
| url | http://dx.doi.org/10.1155/2011/918707 |
| work_keys_str_mv | AT abhijitmgodbole newinsightsintotheandrogentargetedtherapiesandepigenetictherapiesinprostatecancer AT vincentconjar newinsightsintotheandrogentargetedtherapiesandepigenetictherapiesinprostatecancer |