DYSLIPIDEMIA IN NEWBORNS FROM WOMEN WITH GESTATIONAL DIABETES MELLITUS: ARE THE LIPID TRANSPORT SYSTEMS DISRUPTED?
The aim of the research – to evaluate blood lipid spectrum parameters and features of the lipid transport system in newborns from women with gestational diabetes mellitus (GDM). Design – a prospective cohort comparative study was conducted. Materials and methods. A total of 88 newborns were examin...
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| Format: | Article |
| Language: | Russian |
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The Publishing House Medicine and Enlightenment
2025-05-01
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| Series: | Мать и дитя в Кузбассе |
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| Online Access: | https://mednauki.ru/index.php/MD/article/view/1234 |
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| author | Светлана Юрьевна Захарова Карина Сергеевна Ладошина Елена Геннадьевна Дерябина Людмила Анатольевна Пестряева |
| author_facet | Светлана Юрьевна Захарова Карина Сергеевна Ладошина Елена Геннадьевна Дерябина Людмила Анатольевна Пестряева |
| author_sort | Светлана Юрьевна Захарова |
| collection | DOAJ |
| description | The aim of the research – to evaluate blood lipid spectrum parameters and features of the lipid transport system in newborns from women with gestational diabetes mellitus (GDM).
Design – a prospective cohort comparative study was conducted.
Materials and methods. A total of 88 newborns were examined. Including full-term – 40 (45.4%), late premature – 24 (27.2%). The main group consisted of 64 (72.7%) newborns from women with gestational diabetes mellitus. The comparison group consisted of 24 (27.2%) newborns from women without impaired carbohydrate metabolism.
Results. The article presents data on the course of the neonatal period and the features of lipid metabolism in children from women with gestational diabetes mellitus. It is shown that the anthropometric indicators at birth are significantly higher in the main group. The children of the main group also have a higher body mass index (BMI) and ponderal index. The Apgar score was lower in children of the first group. Children of women with GDM had manifestations of diabetic fetopathy (DF) of varying severity. It has been shown that when analyzing the blood lipid spectrum in children from women with GDM, there is dyslipidemia in the form of higher levels of cholesterol (cholesterol), low-density lipoproteins (LDL) and a decrease in the level of high-density lipoproteins (HDL) compared with children from the comparison group. When analyzing the levels of apolipoprotein A-1 (ApoA) and apolipoprotein B (APB) transport proteins, no significant differences were obtained between the studied groups.
Conclusion. Children of women with GSD have high rates of physical development, more often suffer from respiratory disorders requiring respiratory support. Already in the newborn period, these children have dyslipidemia, which requires further study of changes in the lipid transport system at an early age. |
| format | Article |
| id | doaj-art-5308403ec3fa46a2bed36197db7cd8fd |
| institution | DOAJ |
| issn | 1991-010X 2542-0968 |
| language | Russian |
| publishDate | 2025-05-01 |
| publisher | The Publishing House Medicine and Enlightenment |
| record_format | Article |
| series | Мать и дитя в Кузбассе |
| spelling | doaj-art-5308403ec3fa46a2bed36197db7cd8fd2025-08-20T02:48:06ZrusThe Publishing House Medicine and EnlightenmentМать и дитя в Кузбассе1991-010X2542-09682025-05-0126216211051DYSLIPIDEMIA IN NEWBORNS FROM WOMEN WITH GESTATIONAL DIABETES MELLITUS: ARE THE LIPID TRANSPORT SYSTEMS DISRUPTED?Светлана Юрьевна Захарова0Карина Сергеевна Ладошина1Елена Геннадьевна Дерябина2Людмила Анатольевна Пестряева3ФГБУ «НИИ ОММ» Минздрава России, г. ЕкатеринбургФГБУ «НИИ ОММ» Минздрава России, г. ЕкатеринбургФГБУ «НИИ ОММ» Минздрава России, г. ЕкатеринбургФГБУ «НИИ ОММ», Минздрава России, г. ЕкатеринбургThe aim of the research – to evaluate blood lipid spectrum parameters and features of the lipid transport system in newborns from women with gestational diabetes mellitus (GDM). Design – a prospective cohort comparative study was conducted. Materials and methods. A total of 88 newborns were examined. Including full-term – 40 (45.4%), late premature – 24 (27.2%). The main group consisted of 64 (72.7%) newborns from women with gestational diabetes mellitus. The comparison group consisted of 24 (27.2%) newborns from women without impaired carbohydrate metabolism. Results. The article presents data on the course of the neonatal period and the features of lipid metabolism in children from women with gestational diabetes mellitus. It is shown that the anthropometric indicators at birth are significantly higher in the main group. The children of the main group also have a higher body mass index (BMI) and ponderal index. The Apgar score was lower in children of the first group. Children of women with GDM had manifestations of diabetic fetopathy (DF) of varying severity. It has been shown that when analyzing the blood lipid spectrum in children from women with GDM, there is dyslipidemia in the form of higher levels of cholesterol (cholesterol), low-density lipoproteins (LDL) and a decrease in the level of high-density lipoproteins (HDL) compared with children from the comparison group. When analyzing the levels of apolipoprotein A-1 (ApoA) and apolipoprotein B (APB) transport proteins, no significant differences were obtained between the studied groups. Conclusion. Children of women with GSD have high rates of physical development, more often suffer from respiratory disorders requiring respiratory support. Already in the newborn period, these children have dyslipidemia, which requires further study of changes in the lipid transport system at an early age.https://mednauki.ru/index.php/MD/article/view/1234гестационный сахарный диабетноворожденныйлипидный обменлипидтранспортная системагиперинсулинемия |
| spellingShingle | Светлана Юрьевна Захарова Карина Сергеевна Ладошина Елена Геннадьевна Дерябина Людмила Анатольевна Пестряева DYSLIPIDEMIA IN NEWBORNS FROM WOMEN WITH GESTATIONAL DIABETES MELLITUS: ARE THE LIPID TRANSPORT SYSTEMS DISRUPTED? Мать и дитя в Кузбассе гестационный сахарный диабет новорожденный липидный обмен липидтранспортная система гиперинсулинемия |
| title | DYSLIPIDEMIA IN NEWBORNS FROM WOMEN WITH GESTATIONAL DIABETES MELLITUS: ARE THE LIPID TRANSPORT SYSTEMS DISRUPTED? |
| title_full | DYSLIPIDEMIA IN NEWBORNS FROM WOMEN WITH GESTATIONAL DIABETES MELLITUS: ARE THE LIPID TRANSPORT SYSTEMS DISRUPTED? |
| title_fullStr | DYSLIPIDEMIA IN NEWBORNS FROM WOMEN WITH GESTATIONAL DIABETES MELLITUS: ARE THE LIPID TRANSPORT SYSTEMS DISRUPTED? |
| title_full_unstemmed | DYSLIPIDEMIA IN NEWBORNS FROM WOMEN WITH GESTATIONAL DIABETES MELLITUS: ARE THE LIPID TRANSPORT SYSTEMS DISRUPTED? |
| title_short | DYSLIPIDEMIA IN NEWBORNS FROM WOMEN WITH GESTATIONAL DIABETES MELLITUS: ARE THE LIPID TRANSPORT SYSTEMS DISRUPTED? |
| title_sort | dyslipidemia in newborns from women with gestational diabetes mellitus are the lipid transport systems disrupted |
| topic | гестационный сахарный диабет новорожденный липидный обмен липидтранспортная система гиперинсулинемия |
| url | https://mednauki.ru/index.php/MD/article/view/1234 |
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