Hematogones in immune thrombocytopenic purpura: diagnostic implication
Hematogones (HGs) are benign immature B cells in bone marrow with a variety of benign and malignant conditions, including idiopathic thrombocytopenic purpura, leukemia, lymphoma, red blood cell aplasia, iron deficiency anemia, amegakaryocytosis, regenerative bone marrow following viral injury...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2011-04-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1757 |
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| author | Arzu Akyay Mesude Falay Seda Oztürkmen Zafer Biçakci Betül Tavil Gülsüm Ozet Lale Olcay |
| author_facet | Arzu Akyay Mesude Falay Seda Oztürkmen Zafer Biçakci Betül Tavil Gülsüm Ozet Lale Olcay |
| author_sort | Arzu Akyay |
| collection | DOAJ |
| description |
Hematogones (HGs) are benign immature B cells in bone marrow with a variety of benign and malignant conditions, including idiopathic thrombocytopenic purpura, leukemia, lymphoma, red blood cell aplasia, iron deficiency anemia, amegakaryocytosis, regenerative bone marrow following viral injury, chemotherapy or bone marrow transplantation, copper deficiency, autoimmune cytopenias, neuroblastoma, and acquired immunodeficiency syndrome (AIDS). HGs may cause diagnostic problems because of their morphologic and immunophenotypic similarities to neoplastic lymphoblasts. Herein, two patients with thrombocytopenia and three lineage dysplasias in the bone marrow suggesting myelodysplastic syndrome (MDS) with excess blasts are presented. Light microscopic evaluation of marrow from both patients revealed periodic acid-Schiff (PAS)-negative blasts However, flow cytometric analysis revealed excessive HGs in both patients, implying that the cells that were considered as blasts were actually large HGs. Thus, the patients were diagnosed as immune thrombocytopenic purpura due to the isolated thrombocytopenia, large platelets on blood and bone marrow smears and increased megakaryocytes in the bone marrow. These cases emphasize the importance of distinction of hematogone-rich conditions from leukemia and MDS for accurate diagnosis and treatment, and the reliability of multiparameter flow cytometry for the differential diagnosis.
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| format | Article |
| id | doaj-art-5306ae2fb24a456cadfdfdcb085bbd2a |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2011-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-5306ae2fb24a456cadfdfdcb085bbd2a2025-08-20T03:00:54ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212011-04-01532Hematogones in immune thrombocytopenic purpura: diagnostic implicationArzu Akyay0Mesude FalaySeda OztürkmenZafer BiçakciBetül TavilGülsüm OzetLale OlcayUnit of Pediatric Hematology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Turkey. Hematogones (HGs) are benign immature B cells in bone marrow with a variety of benign and malignant conditions, including idiopathic thrombocytopenic purpura, leukemia, lymphoma, red blood cell aplasia, iron deficiency anemia, amegakaryocytosis, regenerative bone marrow following viral injury, chemotherapy or bone marrow transplantation, copper deficiency, autoimmune cytopenias, neuroblastoma, and acquired immunodeficiency syndrome (AIDS). HGs may cause diagnostic problems because of their morphologic and immunophenotypic similarities to neoplastic lymphoblasts. Herein, two patients with thrombocytopenia and three lineage dysplasias in the bone marrow suggesting myelodysplastic syndrome (MDS) with excess blasts are presented. Light microscopic evaluation of marrow from both patients revealed periodic acid-Schiff (PAS)-negative blasts However, flow cytometric analysis revealed excessive HGs in both patients, implying that the cells that were considered as blasts were actually large HGs. Thus, the patients were diagnosed as immune thrombocytopenic purpura due to the isolated thrombocytopenia, large platelets on blood and bone marrow smears and increased megakaryocytes in the bone marrow. These cases emphasize the importance of distinction of hematogone-rich conditions from leukemia and MDS for accurate diagnosis and treatment, and the reliability of multiparameter flow cytometry for the differential diagnosis. https://turkjpediatr.org/article/view/1757 |
| spellingShingle | Arzu Akyay Mesude Falay Seda Oztürkmen Zafer Biçakci Betül Tavil Gülsüm Ozet Lale Olcay Hematogones in immune thrombocytopenic purpura: diagnostic implication The Turkish Journal of Pediatrics |
| title | Hematogones in immune thrombocytopenic purpura: diagnostic implication |
| title_full | Hematogones in immune thrombocytopenic purpura: diagnostic implication |
| title_fullStr | Hematogones in immune thrombocytopenic purpura: diagnostic implication |
| title_full_unstemmed | Hematogones in immune thrombocytopenic purpura: diagnostic implication |
| title_short | Hematogones in immune thrombocytopenic purpura: diagnostic implication |
| title_sort | hematogones in immune thrombocytopenic purpura diagnostic implication |
| url | https://turkjpediatr.org/article/view/1757 |
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