The role of CLDN11 in promotion of granulosa cell proliferation in polycystic ovary syndrome via activation of the PI3K-AKT signalling pathway

The role of CLDN11 in promotion of granulosa cell proliferation in polycystic ovary syndrome via activation of the PI3K-AKT signalling pathway

Abstract Polycystic ovary syndrome (PCOS) is a complex gynecological endocrinological condition that significantly impacts women’s fertility during their reproductive lifespan. The causes of PCOS are multifaceted, and its pathogenesis is not yet clear. This study established a rat model of PCOS and,...

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Bibliographic Details
Main Authors: Min Wang, Tong Chen, Jiani Zheng, Caomeihui Shen, Guitian He, Jingshun Zhang, Boqi Zhang, Lianwen Zheng
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Polycystic ovary syndrome
Granulosa cells
Claudin-11
Follicular development
Proliferation
Online Access:https://doi.org/10.1038/s41598-025-88189-9
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