Predictive value of preclinical models for CAR-T cell therapy clinical trials: a systematic review and meta-analysis

Predictive value of preclinical models for CAR-T cell therapy clinical trials: a systematic review and meta-analysis

Background Experimental mouse models are indispensable for the preclinical development of cancer immunotherapies, whereby complex interactions in the tumor microenvironment can be somewhat replicated. Despite the availability of diverse models, their predictive capacity for clinical outcomes remains...

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Bibliographic Details
Main Authors: Sebastian Kobold, Carsten Marr, David Andreu-Sanz, Lisa Gregor, Emanuele Carlini, Daniele Scarcella
Format: Article
Language:English
Published: BMJ Publishing Group 2025-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/6/e011698.full
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