In Silico Risk Assessment of HLA-A*02:06-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Caused by Cold Medicine Ingredients

In Silico Risk Assessment of HLA-A*02:06-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Caused by Cold Medicine Ingredients

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug hypersensitivities with high mortality. Typical over-the-counter drugs of cold medicines are suggested to be causative. As multiple ingredients are generally contained in cold medicines, it is of particular interest...

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Bibliographic Details
Main Authors: Hideto Isogai, Hiroko Miyadera, Mayumi Ueta, Chie Sotozono, Shigeru Kinoshita, Katsushi Tokunaga, Noriaki Hirayama
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Journal of Toxicology
Online Access:http://dx.doi.org/10.1155/2013/514068
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