A New Scale to Assess the Severity and Prognosis of Pulmonary Alveolar Proteinosis
Background. Pulmonary Alveolar Proteinosis (PAP) is a syndrome characterized by pulmonary surfactant accumulation. Small proportion of PAP patients experienced spontaneous remission. Objective. The aim of this study was to assess the severity and prognosis of PAP using various indexes. Methods. Char...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2016/3412836 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849405796253696000 |
|---|---|
| author | JiuWu Bai JinFu Xu WenLan Yang Beilan Gao Weijun Cao Shuo Liang Huiping Li |
| author_facet | JiuWu Bai JinFu Xu WenLan Yang Beilan Gao Weijun Cao Shuo Liang Huiping Li |
| author_sort | JiuWu Bai |
| collection | DOAJ |
| description | Background. Pulmonary Alveolar Proteinosis (PAP) is a syndrome characterized by pulmonary surfactant accumulation. Small proportion of PAP patients experienced spontaneous remission. Objective. The aim of this study was to assess the severity and prognosis of PAP using various indexes. Methods. Characteristics, PaO2, lung function parameters, and HRCT score of 101 patients with PAP were retrospectively analyzed. Many indexes were explored and integrated into a scale. Results. PaO2 was lower among smokers than among never-smokers. PaO2 differed between each pair of patient groups stratified according to HRCT score or DLCO, % predicted, which differed between any two groups stratified according to PaO2. The PAP patients who died presented with more symptoms, a higher HRCT score, and lower DLCO, % predicted, than survivors. Smoking status, symptoms, PaO2, HRCT score, and DLCO, % predicted, were integrated into a scale (severity and prognosis score of PAP (SPSP)). SPSP correlated positively with PaO2, FVC, % predicted, FEV1, % predicted, and DLCO, % predicted, and negatively with HRCT score. The patients who died displayed a higher SPSP than survivors. Conclusion. Smoking status, symptoms, PaO2, HRCT score, and DLCO, % predicted, were integrated into a scale (SPSP) that can be used to assess the severity and prognosis of PAP to some degree. |
| format | Article |
| id | doaj-art-5302d5599d81483a86bc8db1fd2a1ca0 |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-5302d5599d81483a86bc8db1fd2a1ca02025-08-20T03:36:34ZengWileyCanadian Respiratory Journal1198-22411916-72452016-01-01201610.1155/2016/34128363412836A New Scale to Assess the Severity and Prognosis of Pulmonary Alveolar ProteinosisJiuWu Bai0JinFu Xu1WenLan Yang2Beilan Gao3Weijun Cao4Shuo Liang5Huiping Li6Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Road, Shanghai 200433, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Road, Shanghai 200433, ChinaDepartment of Pulmonary Function Test, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Road, Shanghai 200433, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Road, Shanghai 200433, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Road, Shanghai 200433, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Road, Shanghai 200433, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Road, Shanghai 200433, ChinaBackground. Pulmonary Alveolar Proteinosis (PAP) is a syndrome characterized by pulmonary surfactant accumulation. Small proportion of PAP patients experienced spontaneous remission. Objective. The aim of this study was to assess the severity and prognosis of PAP using various indexes. Methods. Characteristics, PaO2, lung function parameters, and HRCT score of 101 patients with PAP were retrospectively analyzed. Many indexes were explored and integrated into a scale. Results. PaO2 was lower among smokers than among never-smokers. PaO2 differed between each pair of patient groups stratified according to HRCT score or DLCO, % predicted, which differed between any two groups stratified according to PaO2. The PAP patients who died presented with more symptoms, a higher HRCT score, and lower DLCO, % predicted, than survivors. Smoking status, symptoms, PaO2, HRCT score, and DLCO, % predicted, were integrated into a scale (severity and prognosis score of PAP (SPSP)). SPSP correlated positively with PaO2, FVC, % predicted, FEV1, % predicted, and DLCO, % predicted, and negatively with HRCT score. The patients who died displayed a higher SPSP than survivors. Conclusion. Smoking status, symptoms, PaO2, HRCT score, and DLCO, % predicted, were integrated into a scale (SPSP) that can be used to assess the severity and prognosis of PAP to some degree.http://dx.doi.org/10.1155/2016/3412836 |
| spellingShingle | JiuWu Bai JinFu Xu WenLan Yang Beilan Gao Weijun Cao Shuo Liang Huiping Li A New Scale to Assess the Severity and Prognosis of Pulmonary Alveolar Proteinosis Canadian Respiratory Journal |
| title | A New Scale to Assess the Severity and Prognosis of Pulmonary Alveolar Proteinosis |
| title_full | A New Scale to Assess the Severity and Prognosis of Pulmonary Alveolar Proteinosis |
| title_fullStr | A New Scale to Assess the Severity and Prognosis of Pulmonary Alveolar Proteinosis |
| title_full_unstemmed | A New Scale to Assess the Severity and Prognosis of Pulmonary Alveolar Proteinosis |
| title_short | A New Scale to Assess the Severity and Prognosis of Pulmonary Alveolar Proteinosis |
| title_sort | new scale to assess the severity and prognosis of pulmonary alveolar proteinosis |
| url | http://dx.doi.org/10.1155/2016/3412836 |
| work_keys_str_mv | AT jiuwubai anewscaletoassesstheseverityandprognosisofpulmonaryalveolarproteinosis AT jinfuxu anewscaletoassesstheseverityandprognosisofpulmonaryalveolarproteinosis AT wenlanyang anewscaletoassesstheseverityandprognosisofpulmonaryalveolarproteinosis AT beilangao anewscaletoassesstheseverityandprognosisofpulmonaryalveolarproteinosis AT weijuncao anewscaletoassesstheseverityandprognosisofpulmonaryalveolarproteinosis AT shuoliang anewscaletoassesstheseverityandprognosisofpulmonaryalveolarproteinosis AT huipingli anewscaletoassesstheseverityandprognosisofpulmonaryalveolarproteinosis AT jiuwubai newscaletoassesstheseverityandprognosisofpulmonaryalveolarproteinosis AT jinfuxu newscaletoassesstheseverityandprognosisofpulmonaryalveolarproteinosis AT wenlanyang newscaletoassesstheseverityandprognosisofpulmonaryalveolarproteinosis AT beilangao newscaletoassesstheseverityandprognosisofpulmonaryalveolarproteinosis AT weijuncao newscaletoassesstheseverityandprognosisofpulmonaryalveolarproteinosis AT shuoliang newscaletoassesstheseverityandprognosisofpulmonaryalveolarproteinosis AT huipingli newscaletoassesstheseverityandprognosisofpulmonaryalveolarproteinosis |