Peritoneal tuberculosis with elevated serum CA 125 level mimicking advanced ovarian carcinoma in an adolescent

Differential diagnosis between tuberculous peritonitis and peritonitis carcinomatosis is extremely difficult in patients with ascites, peritoneal implants and elevated CA 125 level. A 16-year-old girl presented with abdominal distention, intermittent fever and weight loss. Physical examinatio...

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Main Authors: Funda Corapçioğlu, B Haluk Güvenç, Nazan Sarper, Ayşen Aydoğan, Gür Akansel, Emin Sami Arisoy
Format: Article
Language:English
Published: Hacettepe University Institute of Child Health 2006-01-01
Series:The Turkish Journal of Pediatrics
Online Access:https://turkjpediatr.org/article/view/2599
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author Funda Corapçioğlu
B Haluk Güvenç
Nazan Sarper
Ayşen Aydoğan
Gür Akansel
Emin Sami Arisoy
author_facet Funda Corapçioğlu
B Haluk Güvenç
Nazan Sarper
Ayşen Aydoğan
Gür Akansel
Emin Sami Arisoy
author_sort Funda Corapçioğlu
collection DOAJ
description Differential diagnosis between tuberculous peritonitis and peritonitis carcinomatosis is extremely difficult in patients with ascites, peritoneal implants and elevated CA 125 level. A 16-year-old girl presented with abdominal distention, intermittent fever and weight loss. Physical examination and radiologic studies revealed massive ascites, generalized peritoneal thickening and slightly enlarged right ovary with a cystic mass and left pleural effusion. Serum CA 125 was 939 U/L (normal range: 0-35 U/L) and other tumor markers including alpha fetoprotein (AFP) and beta-human chorionic gonadotropin (HCG) were within normal range. Acid-fast stain and culture were negative for Mycobacterium tuberculosis. Diagnostic laparoscopy and biopsy were performed with the presumptive diagnosis of peritonitis carcinomatosis, and histologic examination revealed multiple granulomas with epithelioid cells and caseification necrosis which confirmed tuberculosis. Quadruple anti-tuberculosis treatment was administered and the patient's clinical findings and serum CA 125 level returned to normal. In conclusion, tuberculous peritonitis should be considered in the differential diagnosis of patients with ascites and elevated serum CA 125. This marker may be useful in monitoring treatment response.
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issn 0041-4301
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language English
publishDate 2006-01-01
publisher Hacettepe University Institute of Child Health
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series The Turkish Journal of Pediatrics
spelling doaj-art-52fa421af93545219ee53200cf9544c02025-08-20T03:00:55ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212006-01-01481Peritoneal tuberculosis with elevated serum CA 125 level mimicking advanced ovarian carcinoma in an adolescentFunda Corapçioğlu0B Haluk GüvençNazan SarperAyşen AydoğanGür AkanselEmin Sami ArisoyDepartment of Pediatrics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey. Differential diagnosis between tuberculous peritonitis and peritonitis carcinomatosis is extremely difficult in patients with ascites, peritoneal implants and elevated CA 125 level. A 16-year-old girl presented with abdominal distention, intermittent fever and weight loss. Physical examination and radiologic studies revealed massive ascites, generalized peritoneal thickening and slightly enlarged right ovary with a cystic mass and left pleural effusion. Serum CA 125 was 939 U/L (normal range: 0-35 U/L) and other tumor markers including alpha fetoprotein (AFP) and beta-human chorionic gonadotropin (HCG) were within normal range. Acid-fast stain and culture were negative for Mycobacterium tuberculosis. Diagnostic laparoscopy and biopsy were performed with the presumptive diagnosis of peritonitis carcinomatosis, and histologic examination revealed multiple granulomas with epithelioid cells and caseification necrosis which confirmed tuberculosis. Quadruple anti-tuberculosis treatment was administered and the patient's clinical findings and serum CA 125 level returned to normal. In conclusion, tuberculous peritonitis should be considered in the differential diagnosis of patients with ascites and elevated serum CA 125. This marker may be useful in monitoring treatment response. https://turkjpediatr.org/article/view/2599
spellingShingle Funda Corapçioğlu
B Haluk Güvenç
Nazan Sarper
Ayşen Aydoğan
Gür Akansel
Emin Sami Arisoy
Peritoneal tuberculosis with elevated serum CA 125 level mimicking advanced ovarian carcinoma in an adolescent
The Turkish Journal of Pediatrics
title Peritoneal tuberculosis with elevated serum CA 125 level mimicking advanced ovarian carcinoma in an adolescent
title_full Peritoneal tuberculosis with elevated serum CA 125 level mimicking advanced ovarian carcinoma in an adolescent
title_fullStr Peritoneal tuberculosis with elevated serum CA 125 level mimicking advanced ovarian carcinoma in an adolescent
title_full_unstemmed Peritoneal tuberculosis with elevated serum CA 125 level mimicking advanced ovarian carcinoma in an adolescent
title_short Peritoneal tuberculosis with elevated serum CA 125 level mimicking advanced ovarian carcinoma in an adolescent
title_sort peritoneal tuberculosis with elevated serum ca 125 level mimicking advanced ovarian carcinoma in an adolescent
url https://turkjpediatr.org/article/view/2599
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