Long‐term efficacy of SGLT2 inhibitors for elderly patients with acute decompensated heart failure: The OASIS‐HF study
Abstract Aims Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) have been widely demonstrated to reduce the risk of cardiovascular death and heart failure (HF) hospitalization, regardless of left ventricular ejection fraction (LVEF). However, data on the extent to which rehospitalization is suppres...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.15088 |
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| author | Michitaka Amioka Hiroki Kinoshita Yuto Fuji Kazuhiro Nitta Kenichi Yamane Tomoki Shokawa Yukiko Nakano |
| author_facet | Michitaka Amioka Hiroki Kinoshita Yuto Fuji Kazuhiro Nitta Kenichi Yamane Tomoki Shokawa Yukiko Nakano |
| author_sort | Michitaka Amioka |
| collection | DOAJ |
| description | Abstract Aims Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) have been widely demonstrated to reduce the risk of cardiovascular death and heart failure (HF) hospitalization, regardless of left ventricular ejection fraction (LVEF). However, data on the extent to which rehospitalization is suppressed following HF hospitalization are limited. This study investigated the effects of SGLT2i on rehospitalization and cardiovascular death. Methods and results The OASIS‐HF study, a multicentre, prospective observational cohort study, enrolled 361 patients aged ≥75 years hospitalized for acute decompensated HF. The impact on composite events of HF rehospitalization or cardiovascular death and the number of annual rehospitalizations were evaluated between the conventional medical therapy and SGLT2i groups. The change in eGFR slope at the 1‐year mark after the initiation of treatment in both groups was also assessed. Over an average follow‐up period of 24.9 months, composite events occurred in 70 (35.4%) of the conventional therapy group and 36 (22.1%) of the SGLT2i group (log‐rank: P = 0.016). The average number of rehospitalizations for HF per year was 0.22 ± 0.13 vs. 0.14 ± 0.08, respectively (P = 0.019). The change in eGFR over 1 year was significantly slower in the SGLT2i group compared with the conventional group (−3.55 ± 8.46 vs. −1.42 ± 7.28 mL/min/1.73 m2, P = 0.025). Conclusions The SGLT2i are not only associated with the reduction of the composite events of HF rehospitalization or cardiovascular death and protect against worsening renal function but also with a decrease in long‐term repeated HF rehospitalizations. |
| format | Article |
| id | doaj-art-52f7c87e155f4041ba4ab3d2f3252de1 |
| institution | OA Journals |
| issn | 2055-5822 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-52f7c87e155f4041ba4ab3d2f3252de12025-08-20T02:16:21ZengWileyESC Heart Failure2055-58222025-02-0112144745510.1002/ehf2.15088Long‐term efficacy of SGLT2 inhibitors for elderly patients with acute decompensated heart failure: The OASIS‐HF studyMichitaka Amioka0Hiroki Kinoshita1Yuto Fuji2Kazuhiro Nitta3Kenichi Yamane4Tomoki Shokawa5Yukiko Nakano6Deparment of Cardiovascular Medicine Shininokuchi Medical Clinic Hiroshima JapanDeparment of Cardiovascular Medicine Onomichi General Hospital Hiroshima JapanDeparment of Cardiovascular Medicine Hiroshima General Hospital Hiroshima JapanDeparment of Cardiovascular Medicine Hiroshima General Hospital Hiroshima JapanDeparment of Cardiovascular Medicine Hiroshima General Hospital Hiroshima JapanDeparment of Cardiovascular Medicine Hiroshima General Hospital Hiroshima JapanDeparment of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima JapanAbstract Aims Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) have been widely demonstrated to reduce the risk of cardiovascular death and heart failure (HF) hospitalization, regardless of left ventricular ejection fraction (LVEF). However, data on the extent to which rehospitalization is suppressed following HF hospitalization are limited. This study investigated the effects of SGLT2i on rehospitalization and cardiovascular death. Methods and results The OASIS‐HF study, a multicentre, prospective observational cohort study, enrolled 361 patients aged ≥75 years hospitalized for acute decompensated HF. The impact on composite events of HF rehospitalization or cardiovascular death and the number of annual rehospitalizations were evaluated between the conventional medical therapy and SGLT2i groups. The change in eGFR slope at the 1‐year mark after the initiation of treatment in both groups was also assessed. Over an average follow‐up period of 24.9 months, composite events occurred in 70 (35.4%) of the conventional therapy group and 36 (22.1%) of the SGLT2i group (log‐rank: P = 0.016). The average number of rehospitalizations for HF per year was 0.22 ± 0.13 vs. 0.14 ± 0.08, respectively (P = 0.019). The change in eGFR over 1 year was significantly slower in the SGLT2i group compared with the conventional group (−3.55 ± 8.46 vs. −1.42 ± 7.28 mL/min/1.73 m2, P = 0.025). Conclusions The SGLT2i are not only associated with the reduction of the composite events of HF rehospitalization or cardiovascular death and protect against worsening renal function but also with a decrease in long‐term repeated HF rehospitalizations.https://doi.org/10.1002/ehf2.15088Cardiovascular deathEjection fractionHeart failureRehospitalizationSodium‐glucose cotransporter 2 inhibitors |
| spellingShingle | Michitaka Amioka Hiroki Kinoshita Yuto Fuji Kazuhiro Nitta Kenichi Yamane Tomoki Shokawa Yukiko Nakano Long‐term efficacy of SGLT2 inhibitors for elderly patients with acute decompensated heart failure: The OASIS‐HF study ESC Heart Failure Cardiovascular death Ejection fraction Heart failure Rehospitalization Sodium‐glucose cotransporter 2 inhibitors |
| title | Long‐term efficacy of SGLT2 inhibitors for elderly patients with acute decompensated heart failure: The OASIS‐HF study |
| title_full | Long‐term efficacy of SGLT2 inhibitors for elderly patients with acute decompensated heart failure: The OASIS‐HF study |
| title_fullStr | Long‐term efficacy of SGLT2 inhibitors for elderly patients with acute decompensated heart failure: The OASIS‐HF study |
| title_full_unstemmed | Long‐term efficacy of SGLT2 inhibitors for elderly patients with acute decompensated heart failure: The OASIS‐HF study |
| title_short | Long‐term efficacy of SGLT2 inhibitors for elderly patients with acute decompensated heart failure: The OASIS‐HF study |
| title_sort | long term efficacy of sglt2 inhibitors for elderly patients with acute decompensated heart failure the oasis hf study |
| topic | Cardiovascular death Ejection fraction Heart failure Rehospitalization Sodium‐glucose cotransporter 2 inhibitors |
| url | https://doi.org/10.1002/ehf2.15088 |
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