Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease
Cytokines play an important role in the immunopathogenesis of inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, where they drive and regulate multiple aspects of intestinal inflammation. The imbalance between proinflammatory and anti-inflammatory cytokines that occu...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/4810258 |
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| _version_ | 1832552430749876224 |
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| author | Qingdong Guan Jiguo Zhang |
| author_facet | Qingdong Guan Jiguo Zhang |
| author_sort | Qingdong Guan |
| collection | DOAJ |
| description | Cytokines play an important role in the immunopathogenesis of inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, where they drive and regulate multiple aspects of intestinal inflammation. The imbalance between proinflammatory and anti-inflammatory cytokines that occurs in IBD results in disease progression and tissue damage and limits the resolution of inflammation. Targeting cytokines have been novel strategies in the treatment of IBD. Recent studies show the beneficial effects of anticytokine treatments to IBD patients, and multiple novel cytokines are found to be involved in the pathogenesis of IBD. In this review, we will discuss the recent advances of novel biologics in clinics and clinical trials, and novel proinflammatory and anti-inflammatory cytokines found in IBD with focusing on IL-12 family and IL-1 family members as well as their relevance to the potential therapy of IBD. |
| format | Article |
| id | doaj-art-52f6ca9dc0a24c7d94ffd6fb952b4997 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-52f6ca9dc0a24c7d94ffd6fb952b49972025-02-03T05:58:42ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/48102584810258Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel DiseaseQingdong Guan0Jiguo Zhang1Institute of Pharmacology, Taishan Medical University, Tai’an, Shandong Province 271016, ChinaInstitute of Pharmacology, Taishan Medical University, Tai’an, Shandong Province 271016, ChinaCytokines play an important role in the immunopathogenesis of inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, where they drive and regulate multiple aspects of intestinal inflammation. The imbalance between proinflammatory and anti-inflammatory cytokines that occurs in IBD results in disease progression and tissue damage and limits the resolution of inflammation. Targeting cytokines have been novel strategies in the treatment of IBD. Recent studies show the beneficial effects of anticytokine treatments to IBD patients, and multiple novel cytokines are found to be involved in the pathogenesis of IBD. In this review, we will discuss the recent advances of novel biologics in clinics and clinical trials, and novel proinflammatory and anti-inflammatory cytokines found in IBD with focusing on IL-12 family and IL-1 family members as well as their relevance to the potential therapy of IBD.http://dx.doi.org/10.1155/2017/4810258 |
| spellingShingle | Qingdong Guan Jiguo Zhang Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease Mediators of Inflammation |
| title | Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease |
| title_full | Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease |
| title_fullStr | Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease |
| title_full_unstemmed | Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease |
| title_short | Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease |
| title_sort | recent advances the imbalance of cytokines in the pathogenesis of inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2017/4810258 |
| work_keys_str_mv | AT qingdongguan recentadvancestheimbalanceofcytokinesinthepathogenesisofinflammatoryboweldisease AT jiguozhang recentadvancestheimbalanceofcytokinesinthepathogenesisofinflammatoryboweldisease |