PROGNOSTIC SIGNIFICANCE OF Ki67, CYCLOOXYGENASE-2 (COX-2) AND p16ink4a IN PATIENTS WITH LOCALLY ADVANCED CERVICAL CANCER
The increased expression levels of Ki67, cyclooxygenase-2 (COX-2) and p16ink4a proteins after neoadjuvant chemotherapy for locally advanced cervical cancer were shown to correlate with unfavorable prognosis. The level of Ki67 expression before treatment was 85 % in patients, who subsequently develop...
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-11-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/402 |
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| author | O. N. Churuksaeva L. A. Kolomiets O. V. Savenkova V. V. Nedosekov M. K. Ibragimova |
| author_facet | O. N. Churuksaeva L. A. Kolomiets O. V. Savenkova V. V. Nedosekov M. K. Ibragimova |
| author_sort | O. N. Churuksaeva |
| collection | DOAJ |
| description | The increased expression levels of Ki67, cyclooxygenase-2 (COX-2) and p16ink4a proteins after neoadjuvant chemotherapy for locally advanced cervical cancer were shown to correlate with unfavorable prognosis. The level of Ki67 expression before treatment was 85 % in patients, who subsequently developed disease progression. The overall 5-year survival rates were significantly higher in cervical cancer patients with Ki67 expression of <50 % than in patients with Ki67 expression >50 %. We found the correlation between COX-2 expression and overall survival of patients with locally advanced cervical cancer. Thus, the 5-year survival rates were 84 % and 66% in cervical cancer patients with COX-2 expressions of <50 % and >50 %, respectively. The correlation between p16ink4a expression and disease-free survival was found. |
| format | Article |
| id | doaj-art-52f55634bb3d41568f7fcc8ef137e4c3 |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-11-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-52f55634bb3d41568f7fcc8ef137e4c32025-08-20T03:18:26ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-11-01155253210.21294/1814-4861-2016-15-5-25-32371PROGNOSTIC SIGNIFICANCE OF Ki67, CYCLOOXYGENASE-2 (COX-2) AND p16ink4a IN PATIENTS WITH LOCALLY ADVANCED CERVICAL CANCERO. N. Churuksaeva0L. A. Kolomiets1O. V. Savenkova2V. V. Nedosekov3M. K. Ibragimova4Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Medical Sciences, Russia, Tomsk 5, Kooperativny Street, 634009-Tomsk, RussiaCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Medical Sciences, Russia, Tomsk 5, Kooperativny Street, 634009-Tomsk, Russia Siberian State Medical University, Russia, TomskCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Medical Sciences, Russia, Tomsk 5, Kooperativny Street, 634009-Tomsk, RussiaSiberian State Medical University, Russia, Tomsk2Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Medical Sciences, Russia, Tomsk 5, Kooperativny Street, 634009-Tomsk, RussiaThe increased expression levels of Ki67, cyclooxygenase-2 (COX-2) and p16ink4a proteins after neoadjuvant chemotherapy for locally advanced cervical cancer were shown to correlate with unfavorable prognosis. The level of Ki67 expression before treatment was 85 % in patients, who subsequently developed disease progression. The overall 5-year survival rates were significantly higher in cervical cancer patients with Ki67 expression of <50 % than in patients with Ki67 expression >50 %. We found the correlation between COX-2 expression and overall survival of patients with locally advanced cervical cancer. Thus, the 5-year survival rates were 84 % and 66% in cervical cancer patients with COX-2 expressions of <50 % and >50 %, respectively. The correlation between p16ink4a expression and disease-free survival was found.https://www.siboncoj.ru/jour/article/view/402locally advanced cervical cancerki67cox-2p16ink4aprognostic factors |
| spellingShingle | O. N. Churuksaeva L. A. Kolomiets O. V. Savenkova V. V. Nedosekov M. K. Ibragimova PROGNOSTIC SIGNIFICANCE OF Ki67, CYCLOOXYGENASE-2 (COX-2) AND p16ink4a IN PATIENTS WITH LOCALLY ADVANCED CERVICAL CANCER Сибирский онкологический журнал locally advanced cervical cancer ki67 cox-2 p16ink4a prognostic factors |
| title | PROGNOSTIC SIGNIFICANCE OF Ki67, CYCLOOXYGENASE-2 (COX-2) AND p16ink4a IN PATIENTS WITH LOCALLY ADVANCED CERVICAL CANCER |
| title_full | PROGNOSTIC SIGNIFICANCE OF Ki67, CYCLOOXYGENASE-2 (COX-2) AND p16ink4a IN PATIENTS WITH LOCALLY ADVANCED CERVICAL CANCER |
| title_fullStr | PROGNOSTIC SIGNIFICANCE OF Ki67, CYCLOOXYGENASE-2 (COX-2) AND p16ink4a IN PATIENTS WITH LOCALLY ADVANCED CERVICAL CANCER |
| title_full_unstemmed | PROGNOSTIC SIGNIFICANCE OF Ki67, CYCLOOXYGENASE-2 (COX-2) AND p16ink4a IN PATIENTS WITH LOCALLY ADVANCED CERVICAL CANCER |
| title_short | PROGNOSTIC SIGNIFICANCE OF Ki67, CYCLOOXYGENASE-2 (COX-2) AND p16ink4a IN PATIENTS WITH LOCALLY ADVANCED CERVICAL CANCER |
| title_sort | prognostic significance of ki67 cyclooxygenase 2 cox 2 and p16ink4a in patients with locally advanced cervical cancer |
| topic | locally advanced cervical cancer ki67 cox-2 p16ink4a prognostic factors |
| url | https://www.siboncoj.ru/jour/article/view/402 |
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