PROGNOSTIC SIGNIFICANCE OF Ki67, CYCLOOXYGENASE-2 (COX-2) AND p16ink4a IN PATIENTS WITH LOCALLY ADVANCED CERVICAL CANCER
The increased expression levels of Ki67, cyclooxygenase-2 (COX-2) and p16ink4a proteins after neoadjuvant chemotherapy for locally advanced cervical cancer were shown to correlate with unfavorable prognosis. The level of Ki67 expression before treatment was 85 % in patients, who subsequently develop...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2016-11-01
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| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/402 |
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| Summary: | The increased expression levels of Ki67, cyclooxygenase-2 (COX-2) and p16ink4a proteins after neoadjuvant chemotherapy for locally advanced cervical cancer were shown to correlate with unfavorable prognosis. The level of Ki67 expression before treatment was 85 % in patients, who subsequently developed disease progression. The overall 5-year survival rates were significantly higher in cervical cancer patients with Ki67 expression of <50 % than in patients with Ki67 expression >50 %. We found the correlation between COX-2 expression and overall survival of patients with locally advanced cervical cancer. Thus, the 5-year survival rates were 84 % and 66% in cervical cancer patients with COX-2 expressions of <50 % and >50 %, respectively. The correlation between p16ink4a expression and disease-free survival was found. |
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| ISSN: | 1814-4861 2312-3168 |