The role of HLA-G in primary biliary cholangitis and response to therapy

The role of HLA-G in primary biliary cholangitis and response to therapy

IntroductionPrimary biliary cholangitis (PBC) is a rare autoimmune liver disease involving bile duct damage and fibrosis. This study explores the role of HLA-G, an immunomodulatory molecule crucial for immune tolerance, in PBC pathogenesis and treatment.MethodsA cohort of 166 PBC patients from Sardi...

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Main Authors: Michela Miglianti, Stefano Mocci, Roberto Littera, Giancarlo Serra, Cinzia Balestieri, Maria Conti, Francesco Pes, Silvia Deidda, Michela Lorrai, Caterina Mereu, Michela Murgia, Celeste Sanna, Alessia Mascia, Francesca Sedda, Irena Duś-Ilnicka, Selene Cipri, Mauro Giovanni Carta, Sara Lai, Erika Giuressi, Maurizio Melis, Teresa Zolfino, Sabrina Giglio, Andrea Perra, Luchino Chessa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
HLA-G
primary biliary cholangitis
ursodeoxicholic acid
Sardinia (Italy)
autoimmune diseases
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1585535/full
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