Pregnancy Complications and Outcomes in Obese Women with Gestational Diabetes
<i>Background and Objectives</i>: To assess pregnancy and delivery complications in obese women with gestational diabetes mellitus (GDM) and neonatal weight and condition after birth. <i>Materials and Methods</i>: A retrospective tertiary referral centre study included all ca...
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2025-01-01
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| author | Gitana Ramonienė Laura Malakauskienė Eglė Savukynė Laima Maleckienė Greta Gruzdaitė |
| author_facet | Gitana Ramonienė Laura Malakauskienė Eglė Savukynė Laima Maleckienė Greta Gruzdaitė |
| author_sort | Gitana Ramonienė |
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| description | <i>Background and Objectives</i>: To assess pregnancy and delivery complications in obese women with gestational diabetes mellitus (GDM) and neonatal weight and condition after birth. <i>Materials and Methods</i>: A retrospective tertiary referral centre study included all cases of GDM in the Department of Obstetrics and Gynaecology of the Lithuanian University of Health Sciences (LUHS) Birth Registry from 1 January 2019 to 31 December 2019. We included 583 women with GDM and singleton pregnancies. Women were divided into two groups according to their pre-pregnancy weight: 202 were obese (BMI ≥ 30 kg/m<sup>2</sup>), and 381 were weight (BMI 18.5–24.9 kg/m<sup>2</sup>). Survey data were analysed using IBM SPSS Statistics 26.0 and MS Excel 2016 software. A value of <i>p</i> < 0.05 was considered significant. <i>Results</i>: Fasting glycaemia was significantly higher in obese women with GDM than in normal-weight women with GDM (<i>p</i> < 0.001). In addition, fasting glycaemia was higher in obese women with GDM requiring insulin correction than in normal-weight women (<i>p</i> = 0.006). OGTT 0-min glycaemia was higher in obese than in non-obese women with gestational diabetes (<i>p</i> < 0.001). Women with pre-pregnancy obesity had a higher incidence of primary hypertension (<i>p</i> < 0.001), hypertensive disorders in pregnancy (<i>p</i> < 0.001), gestational cholestasis (<i>p</i> = 0.002), polyhydramnios (<i>p</i> < 0.001), induced labour (<i>p</i> < 0.001), and caesarean section (<i>p</i> = 0.015), with emergency caesarean sections being more frequent than planned caesarean sections (<i>p</i> = 0.011) compared to normal-weight women with GDM. Labour dystocia (<i>p</i> = 0.003) and foetal distress (<i>p</i> = 0,019) were more common during labour in obese women. Neonates of these women more often had macrosomia (<i>p</i> < 0.001) and lower Apgar scores at 1 min (<i>p</i> = 0.024) and at 5 min (<i>p</i> = 0.024) compared to neonates of normal-weight women. <i>Conclusions</i>: Obese women with GDM experience more pregnancy complications than normal-weight women with GDM. |
| format | Article |
| id | doaj-art-52eef4830a9e49c592ee8000fdaba354 |
| institution | Kabale University |
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| publishDate | 2025-01-01 |
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| spelling | doaj-art-52eef4830a9e49c592ee8000fdaba3542025-01-24T13:40:23ZengMDPI AGMedicina1010-660X1648-91442025-01-016115110.3390/medicina61010051Pregnancy Complications and Outcomes in Obese Women with Gestational DiabetesGitana Ramonienė0Laura Malakauskienė1Eglė Savukynė2Laima Maleckienė3Greta Gruzdaitė4Department of Obstetrics and Gynaecology, Medical Academy, Lithuanian University of Health Sciences, A. Mickevicius St. 7, 44307 Kaunas, LithuaniaDepartment of Obstetrics and Gynaecology, Medical Academy, Lithuanian University of Health Sciences, A. Mickevicius St. 7, 44307 Kaunas, LithuaniaDepartment of Obstetrics and Gynaecology, Medical Academy, Lithuanian University of Health Sciences, A. Mickevicius St. 7, 44307 Kaunas, LithuaniaDepartment of Obstetrics and Gynaecology, Medical Academy, Lithuanian University of Health Sciences, A. Mickevicius St. 7, 44307 Kaunas, LithuaniaDepartment of Obstetrics and Gynaecology, Medical Academy, Lithuanian University of Health Sciences, A. Mickevicius St. 7, 44307 Kaunas, Lithuania<i>Background and Objectives</i>: To assess pregnancy and delivery complications in obese women with gestational diabetes mellitus (GDM) and neonatal weight and condition after birth. <i>Materials and Methods</i>: A retrospective tertiary referral centre study included all cases of GDM in the Department of Obstetrics and Gynaecology of the Lithuanian University of Health Sciences (LUHS) Birth Registry from 1 January 2019 to 31 December 2019. We included 583 women with GDM and singleton pregnancies. Women were divided into two groups according to their pre-pregnancy weight: 202 were obese (BMI ≥ 30 kg/m<sup>2</sup>), and 381 were weight (BMI 18.5–24.9 kg/m<sup>2</sup>). Survey data were analysed using IBM SPSS Statistics 26.0 and MS Excel 2016 software. A value of <i>p</i> < 0.05 was considered significant. <i>Results</i>: Fasting glycaemia was significantly higher in obese women with GDM than in normal-weight women with GDM (<i>p</i> < 0.001). In addition, fasting glycaemia was higher in obese women with GDM requiring insulin correction than in normal-weight women (<i>p</i> = 0.006). OGTT 0-min glycaemia was higher in obese than in non-obese women with gestational diabetes (<i>p</i> < 0.001). Women with pre-pregnancy obesity had a higher incidence of primary hypertension (<i>p</i> < 0.001), hypertensive disorders in pregnancy (<i>p</i> < 0.001), gestational cholestasis (<i>p</i> = 0.002), polyhydramnios (<i>p</i> < 0.001), induced labour (<i>p</i> < 0.001), and caesarean section (<i>p</i> = 0.015), with emergency caesarean sections being more frequent than planned caesarean sections (<i>p</i> = 0.011) compared to normal-weight women with GDM. Labour dystocia (<i>p</i> = 0.003) and foetal distress (<i>p</i> = 0,019) were more common during labour in obese women. Neonates of these women more often had macrosomia (<i>p</i> < 0.001) and lower Apgar scores at 1 min (<i>p</i> = 0.024) and at 5 min (<i>p</i> = 0.024) compared to neonates of normal-weight women. <i>Conclusions</i>: Obese women with GDM experience more pregnancy complications than normal-weight women with GDM.https://www.mdpi.com/1648-9144/61/1/51gestational diabetesobesitypregnancy complicationslabour complications |
| spellingShingle | Gitana Ramonienė Laura Malakauskienė Eglė Savukynė Laima Maleckienė Greta Gruzdaitė Pregnancy Complications and Outcomes in Obese Women with Gestational Diabetes Medicina gestational diabetes obesity pregnancy complications labour complications |
| title | Pregnancy Complications and Outcomes in Obese Women with Gestational Diabetes |
| title_full | Pregnancy Complications and Outcomes in Obese Women with Gestational Diabetes |
| title_fullStr | Pregnancy Complications and Outcomes in Obese Women with Gestational Diabetes |
| title_full_unstemmed | Pregnancy Complications and Outcomes in Obese Women with Gestational Diabetes |
| title_short | Pregnancy Complications and Outcomes in Obese Women with Gestational Diabetes |
| title_sort | pregnancy complications and outcomes in obese women with gestational diabetes |
| topic | gestational diabetes obesity pregnancy complications labour complications |
| url | https://www.mdpi.com/1648-9144/61/1/51 |
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