Abstract 109: Endonasal Endoscopic Approach Associated Cerebral Vasospasm and Management: A Case Report
Introduction Endoscopic endonasal approach(EEA) techniques have been increasingly utilized and have been associated with development of cerebrospinal fluid(CSF) leak, meningitis, diabetes insipidus post‐operatively. Cerebral vasospasm following EEA has rarely been described. Here, we describe the cl...
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Wiley
2023-11-01
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| Series: | Stroke: Vascular and Interventional Neurology |
| Online Access: | https://www.ahajournals.org/doi/10.1161/SVIN.03.suppl_2.109 |
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| author | Nefize P. Turan Matthew Bower Abdullah Bin Zahid Ryan P. Lee Shih‐Chun Lin Murugappan Ramanathan Jr Adam Schiavi Justin M. Caplan |
| author_facet | Nefize P. Turan Matthew Bower Abdullah Bin Zahid Ryan P. Lee Shih‐Chun Lin Murugappan Ramanathan Jr Adam Schiavi Justin M. Caplan |
| author_sort | Nefize P. Turan |
| collection | DOAJ |
| description | Introduction Endoscopic endonasal approach(EEA) techniques have been increasingly utilized and have been associated with development of cerebrospinal fluid(CSF) leak, meningitis, diabetes insipidus post‐operatively. Cerebral vasospasm following EEA has rarely been described. Here, we describe the clinical course and management of a patient who underwent EEA for encephalocele repair whose course was complicated by postoperative subarachnoid hemorrhage(SAH) and cerebral vasospasm. Methods n/a Results Case Presentation: 40 year old female with past medical history significant for cerebral venous sinus stent on aspirin, CSF rhinorrhea secondary to right nasal encephalocele s/p endoscopic transnasal transethmoidal repair with nasoseptal flap reconstruction and lumbar drain placement eleven days prior presented with speech difficulties and right sided weakness. On exam, patient was noted to have mild right hemiparesis and expressive aphasia. MRI brain showed subacute infarcts in left greater than right frontal lobes, corpus collosum and right anterior perforated substance. MRA head demonstrated multifocal arterial stenosis. In light of postoperative CT head showing SAH in the basilar, perimesencephalic, prepontine cisterns, interhemispheric fissure and right frontal sulci as well as intraventricular hemorrhage in fourth ventricle, her presentation was thought to be secondary to cerebral vasospasm in the setting of postoperative SAH. She was treated with intravenous hydration, permissive hypertension with head of bed in flat position and transferred for further evaluation. On arrival, she continued have mild right hemiparesis and aphasia. Repeat CTA head/neck and CT perfusion showed severe stenosis of bilateral M1 segments and left greater than right A1 segments as well as ischemic penumbra in left ACA/MCA watershed territory. Diagnostic cerebral angiogram showed bilateral severe A1 stenosis and mild to moderate bilateral M1 and supraclinoid ICA stenosis which improved with intra‐arterial verapamil. She was started on nimodipine. Systolic blood pressure was augmented with vasopressors for goal of 150‐180mmHg. Daily TCDs were followed. She developed worsening right leg weakness following day, thus she was taken for repeat diagnostic cerebral angiogram during which time she was re‐administered intra‐arterial verapamil with improvement in vasospasm. After the second treatment, she had improvement in speech and motor strength. Systolic blood pressure goal was gradually normalized. She was noted to have incidental left internal jugular (IJ) vein thrombosis for which anticoagulation was held in the setting of recent neurosurgical procedure and SAH. Workup for vasculitis and hypercoagulability was unrevealing. Lumbar puncture demonstrated 13 WBC/cu mm with lymphocytic predominance(90%), 23 RBC/cu mm, glucose 89mg/dl, protein 30mg/dl. CSF cultures were negative. Pleocytosis in CSF was attributed to recent neurosurgical procedure. Her neurological exam improved to baseline on hospital day(HD) 9.On HD12, she was found to have left common femoral deep venous thrombus in addition to the left IJ thrombus. Anticoagulation with low dose heparin infusion was started which was transitioned to apixaban on discharge. She was discharged home on HD20. Conclusion We report a case of EEA associated with severe multifocal cerebral vasospasm secondary to postoperative SAH that was successfully treated with induced hypertension, oral nimodipine and intra‐arterial verapamil as an adjunct therapy with an excellent outcome. |
| format | Article |
| id | doaj-art-52ec1169600d4c8b8f175dffb70b271a |
| institution | DOAJ |
| issn | 2694-5746 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke: Vascular and Interventional Neurology |
| spelling | doaj-art-52ec1169600d4c8b8f175dffb70b271a2025-08-20T03:08:46ZengWileyStroke: Vascular and Interventional Neurology2694-57462023-11-013S210.1161/SVIN.03.suppl_2.109Abstract 109: Endonasal Endoscopic Approach Associated Cerebral Vasospasm and Management: A Case ReportNefize P. Turan0Matthew Bower1Abdullah Bin Zahid2Ryan P. Lee3Shih‐Chun Lin4Murugappan Ramanathan Jr5Adam Schiavi6Justin M. Caplan7Department of Neurology Johns Hopkins University School of Medicine Maryland United StatesDepartment of Neurology Johns Hopkins University School of Medicine Maryland United StatesDepartment of Neurology Johns Hopkins University School of Medicine Maryland United StatesDepartment of Neurosurgery Johns Hopkins University School of Medicine Maryland United StatesDepartment of Neurosurgery Johns Hopkins University School of Medicine Maryland United StatesDepartment of Otolaryngology Johns Hopkins University School of Medicine Maryland United StatesDepartment of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Maryland United StatesDepartment of Neurosurgery Johns Hopkins University School of Medicine Maryland United StatesIntroduction Endoscopic endonasal approach(EEA) techniques have been increasingly utilized and have been associated with development of cerebrospinal fluid(CSF) leak, meningitis, diabetes insipidus post‐operatively. Cerebral vasospasm following EEA has rarely been described. Here, we describe the clinical course and management of a patient who underwent EEA for encephalocele repair whose course was complicated by postoperative subarachnoid hemorrhage(SAH) and cerebral vasospasm. Methods n/a Results Case Presentation: 40 year old female with past medical history significant for cerebral venous sinus stent on aspirin, CSF rhinorrhea secondary to right nasal encephalocele s/p endoscopic transnasal transethmoidal repair with nasoseptal flap reconstruction and lumbar drain placement eleven days prior presented with speech difficulties and right sided weakness. On exam, patient was noted to have mild right hemiparesis and expressive aphasia. MRI brain showed subacute infarcts in left greater than right frontal lobes, corpus collosum and right anterior perforated substance. MRA head demonstrated multifocal arterial stenosis. In light of postoperative CT head showing SAH in the basilar, perimesencephalic, prepontine cisterns, interhemispheric fissure and right frontal sulci as well as intraventricular hemorrhage in fourth ventricle, her presentation was thought to be secondary to cerebral vasospasm in the setting of postoperative SAH. She was treated with intravenous hydration, permissive hypertension with head of bed in flat position and transferred for further evaluation. On arrival, she continued have mild right hemiparesis and aphasia. Repeat CTA head/neck and CT perfusion showed severe stenosis of bilateral M1 segments and left greater than right A1 segments as well as ischemic penumbra in left ACA/MCA watershed territory. Diagnostic cerebral angiogram showed bilateral severe A1 stenosis and mild to moderate bilateral M1 and supraclinoid ICA stenosis which improved with intra‐arterial verapamil. She was started on nimodipine. Systolic blood pressure was augmented with vasopressors for goal of 150‐180mmHg. Daily TCDs were followed. She developed worsening right leg weakness following day, thus she was taken for repeat diagnostic cerebral angiogram during which time she was re‐administered intra‐arterial verapamil with improvement in vasospasm. After the second treatment, she had improvement in speech and motor strength. Systolic blood pressure goal was gradually normalized. She was noted to have incidental left internal jugular (IJ) vein thrombosis for which anticoagulation was held in the setting of recent neurosurgical procedure and SAH. Workup for vasculitis and hypercoagulability was unrevealing. Lumbar puncture demonstrated 13 WBC/cu mm with lymphocytic predominance(90%), 23 RBC/cu mm, glucose 89mg/dl, protein 30mg/dl. CSF cultures were negative. Pleocytosis in CSF was attributed to recent neurosurgical procedure. Her neurological exam improved to baseline on hospital day(HD) 9.On HD12, she was found to have left common femoral deep venous thrombus in addition to the left IJ thrombus. Anticoagulation with low dose heparin infusion was started which was transitioned to apixaban on discharge. She was discharged home on HD20. Conclusion We report a case of EEA associated with severe multifocal cerebral vasospasm secondary to postoperative SAH that was successfully treated with induced hypertension, oral nimodipine and intra‐arterial verapamil as an adjunct therapy with an excellent outcome.https://www.ahajournals.org/doi/10.1161/SVIN.03.suppl_2.109 |
| spellingShingle | Nefize P. Turan Matthew Bower Abdullah Bin Zahid Ryan P. Lee Shih‐Chun Lin Murugappan Ramanathan Jr Adam Schiavi Justin M. Caplan Abstract 109: Endonasal Endoscopic Approach Associated Cerebral Vasospasm and Management: A Case Report Stroke: Vascular and Interventional Neurology |
| title | Abstract 109: Endonasal Endoscopic Approach Associated Cerebral Vasospasm and Management: A Case Report |
| title_full | Abstract 109: Endonasal Endoscopic Approach Associated Cerebral Vasospasm and Management: A Case Report |
| title_fullStr | Abstract 109: Endonasal Endoscopic Approach Associated Cerebral Vasospasm and Management: A Case Report |
| title_full_unstemmed | Abstract 109: Endonasal Endoscopic Approach Associated Cerebral Vasospasm and Management: A Case Report |
| title_short | Abstract 109: Endonasal Endoscopic Approach Associated Cerebral Vasospasm and Management: A Case Report |
| title_sort | abstract 109 endonasal endoscopic approach associated cerebral vasospasm and management a case report |
| url | https://www.ahajournals.org/doi/10.1161/SVIN.03.suppl_2.109 |
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