A Pilot Study of a Novel through-the-Scope Self-Expandable Metallic Airway Stents Delivery System in Malignant Central Airway Obstruction
Objective. Self-expandable metallic (SEM) airway stents are an important approach to malignant central airway obstruction (CAO). SEM airway stent insertions are usually performed under fluoroscopic guidance over a guide wire placed through a flexible bronchoscope often resulting in a longer procedur...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2019/7828526 |
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| author | Jun-hong Jiang Da-xiong Zeng Chang-guo Wang Yan-bin Chen Dan Shen Jin-yu Mao J. Francis Turner Jian-an Huang |
| author_facet | Jun-hong Jiang Da-xiong Zeng Chang-guo Wang Yan-bin Chen Dan Shen Jin-yu Mao J. Francis Turner Jian-an Huang |
| author_sort | Jun-hong Jiang |
| collection | DOAJ |
| description | Objective. Self-expandable metallic (SEM) airway stents are an important approach to malignant central airway obstruction (CAO). SEM airway stent insertions are usually performed under fluoroscopic guidance over a guide wire placed through a flexible bronchoscope often resulting in a longer procedure time and exposure to radiation. In this pilot study, we designed a novel delivery system of the through-the-scope (TTS) SEM airway stent insertion and observed its feasibility. Methods. From Jan 2015 to Sept 2016, 25 consecutive patients with inoperable malignant CAO were enrolled requiring airway stent implantation. All patients were followed up to death or at least 6 months. Results. 36 TTS stents were inserted into 25 patients using a flexible bronchoscope under general anesthesia or local anesthesia. All stents were successfully deployed directly through the working channel (2.8 mm diameter) of the flexible bronchoscope in 91.7% (33/36) of the subjects. The mMRC score and stenosis grade improved significantly after stent implantation. The common stent-related complications were secretion retention (25%, 9/36), development of granulation tissue (13.9%, 5/36), tumor in-growth (13.9%, 5/36), and hemoptysis (8.3%, 3/36). The 6-month overall survival (OS) was 44% (11/25). Conclusion. The novel TTS stent release system was an effective and safe approach in malignant central airway obstruction. |
| format | Article |
| id | doaj-art-52e90aeb68cd40569cd203da8d776df8 |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-52e90aeb68cd40569cd203da8d776df82025-08-20T03:36:34ZengWileyCanadian Respiratory Journal1198-22411916-72452019-01-01201910.1155/2019/78285267828526A Pilot Study of a Novel through-the-Scope Self-Expandable Metallic Airway Stents Delivery System in Malignant Central Airway ObstructionJun-hong Jiang0Da-xiong Zeng1Chang-guo Wang2Yan-bin Chen3Dan Shen4Jin-yu Mao5J. Francis Turner6Jian-an Huang7Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Medicine, Division of Pulmonary & Critical Care Medicine, University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, U114, Knoxville, TN 37920-6999, USADepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, ChinaObjective. Self-expandable metallic (SEM) airway stents are an important approach to malignant central airway obstruction (CAO). SEM airway stent insertions are usually performed under fluoroscopic guidance over a guide wire placed through a flexible bronchoscope often resulting in a longer procedure time and exposure to radiation. In this pilot study, we designed a novel delivery system of the through-the-scope (TTS) SEM airway stent insertion and observed its feasibility. Methods. From Jan 2015 to Sept 2016, 25 consecutive patients with inoperable malignant CAO were enrolled requiring airway stent implantation. All patients were followed up to death or at least 6 months. Results. 36 TTS stents were inserted into 25 patients using a flexible bronchoscope under general anesthesia or local anesthesia. All stents were successfully deployed directly through the working channel (2.8 mm diameter) of the flexible bronchoscope in 91.7% (33/36) of the subjects. The mMRC score and stenosis grade improved significantly after stent implantation. The common stent-related complications were secretion retention (25%, 9/36), development of granulation tissue (13.9%, 5/36), tumor in-growth (13.9%, 5/36), and hemoptysis (8.3%, 3/36). The 6-month overall survival (OS) was 44% (11/25). Conclusion. The novel TTS stent release system was an effective and safe approach in malignant central airway obstruction.http://dx.doi.org/10.1155/2019/7828526 |
| spellingShingle | Jun-hong Jiang Da-xiong Zeng Chang-guo Wang Yan-bin Chen Dan Shen Jin-yu Mao J. Francis Turner Jian-an Huang A Pilot Study of a Novel through-the-Scope Self-Expandable Metallic Airway Stents Delivery System in Malignant Central Airway Obstruction Canadian Respiratory Journal |
| title | A Pilot Study of a Novel through-the-Scope Self-Expandable Metallic Airway Stents Delivery System in Malignant Central Airway Obstruction |
| title_full | A Pilot Study of a Novel through-the-Scope Self-Expandable Metallic Airway Stents Delivery System in Malignant Central Airway Obstruction |
| title_fullStr | A Pilot Study of a Novel through-the-Scope Self-Expandable Metallic Airway Stents Delivery System in Malignant Central Airway Obstruction |
| title_full_unstemmed | A Pilot Study of a Novel through-the-Scope Self-Expandable Metallic Airway Stents Delivery System in Malignant Central Airway Obstruction |
| title_short | A Pilot Study of a Novel through-the-Scope Self-Expandable Metallic Airway Stents Delivery System in Malignant Central Airway Obstruction |
| title_sort | pilot study of a novel through the scope self expandable metallic airway stents delivery system in malignant central airway obstruction |
| url | http://dx.doi.org/10.1155/2019/7828526 |
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