Molecular Signatures of Radiation Response in Breast Cancer: Towards Personalized Decision-Making in Radiation Treatment
Recent advances in gene expression profiling have allowed for a more sophisticated understanding of the biology of breast cancers. These advances led to the development of molecular signatures that now allow clinicians to more individually tailor recommendations regarding the utility and necessity o...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2017/4279724 |
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| _version_ | 1850226049199112192 |
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| author | Corey Speers Lori J. Pierce |
| author_facet | Corey Speers Lori J. Pierce |
| author_sort | Corey Speers |
| collection | DOAJ |
| description | Recent advances in gene expression profiling have allowed for a more sophisticated understanding of the biology of breast cancers. These advances led to the development of molecular signatures that now allow clinicians to more individually tailor recommendations regarding the utility and necessity of systemic therapies for women with breast cancer. Indeed, these molecularly based tests have been incorporated into national and international best practice guidelines and are now part of routine practice. Similar, though slower, progress is being made in the development of molecular signatures predictive of radiation response and necessity for women with breast cancer. This article will discuss the history of radiation response signature development, the current state of these signatures under ongoing clinical development, the barriers to their clinical adoption, and upcoming changes and opportunities that may allow for the personalized radiation treatment recommendations enabled by the development of these signatures. |
| format | Article |
| id | doaj-art-52e5d924eb004c92a8aac1a8b543e772 |
| institution | OA Journals |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-52e5d924eb004c92a8aac1a8b543e7722025-08-20T02:05:11ZengWileyInternational Journal of Breast Cancer2090-31702090-31892017-01-01201710.1155/2017/42797244279724Molecular Signatures of Radiation Response in Breast Cancer: Towards Personalized Decision-Making in Radiation TreatmentCorey Speers0Lori J. Pierce1Department of Radiation Oncology, Michigan Medicine, Ann Arbor, MI, USADepartment of Radiation Oncology, Michigan Medicine, Ann Arbor, MI, USARecent advances in gene expression profiling have allowed for a more sophisticated understanding of the biology of breast cancers. These advances led to the development of molecular signatures that now allow clinicians to more individually tailor recommendations regarding the utility and necessity of systemic therapies for women with breast cancer. Indeed, these molecularly based tests have been incorporated into national and international best practice guidelines and are now part of routine practice. Similar, though slower, progress is being made in the development of molecular signatures predictive of radiation response and necessity for women with breast cancer. This article will discuss the history of radiation response signature development, the current state of these signatures under ongoing clinical development, the barriers to their clinical adoption, and upcoming changes and opportunities that may allow for the personalized radiation treatment recommendations enabled by the development of these signatures.http://dx.doi.org/10.1155/2017/4279724 |
| spellingShingle | Corey Speers Lori J. Pierce Molecular Signatures of Radiation Response in Breast Cancer: Towards Personalized Decision-Making in Radiation Treatment International Journal of Breast Cancer |
| title | Molecular Signatures of Radiation Response in Breast Cancer: Towards Personalized Decision-Making in Radiation Treatment |
| title_full | Molecular Signatures of Radiation Response in Breast Cancer: Towards Personalized Decision-Making in Radiation Treatment |
| title_fullStr | Molecular Signatures of Radiation Response in Breast Cancer: Towards Personalized Decision-Making in Radiation Treatment |
| title_full_unstemmed | Molecular Signatures of Radiation Response in Breast Cancer: Towards Personalized Decision-Making in Radiation Treatment |
| title_short | Molecular Signatures of Radiation Response in Breast Cancer: Towards Personalized Decision-Making in Radiation Treatment |
| title_sort | molecular signatures of radiation response in breast cancer towards personalized decision making in radiation treatment |
| url | http://dx.doi.org/10.1155/2017/4279724 |
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