Donor and recipient genetic variants in drug metabolizing enzymes and transporters affect early tacrolimus pharmacokinetics after liver transplantation

Donor and recipient genetic variants in drug metabolizing enzymes and transporters affect early tacrolimus pharmacokinetics after liver transplantation

Abstract This study examines the influence of single nucleotide polymorphisms in drug metabolizing enzymes CYP3A4, CYP3A5, and UGT1A4, and the transporter ABCB1 on tacrolimus dose requirements and blood trough level variability in the period immediately after liver transplantation. We analyzed genot...

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Bibliographic Details
Main Authors: Alexandra D. Ladd, Isabella Angeli-Pahim, Duncan Lewis, Curtis Warren, Satyavardhan Nittu, Jatinder Lamba, Sergio Duarte, Ali Zarrinpar
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Tacrolimus
Pharmacogenetics
Pharmacokinetics
Single nucleotide polymorphism
CYP3A4
CYP3A5
Online Access:https://doi.org/10.1038/s41598-025-09296-1
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https://doi.org/10.1038/s41598-025-09296-1

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