Nicotinamide mononucleotide improves the ovarian reserve of POI by inhibiting NLRP3-mediated pyroptosis of ovarian granulosa cells

Nicotinamide mononucleotide improves the ovarian reserve of POI by inhibiting NLRP3-mediated pyroptosis of ovarian granulosa cells

Abstract Background Premature ovarian insufficiency (POI) is a common clinical problem, but there is currently no effective treatment. NLRP3 inflammasome-induced pyroptosis is thought to be a possible mechanism of POI. Nicotinamide mononucleotide (NMN) has a certain anti-inflammatory effect, providi...

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Bibliographic Details
Main Authors: Yue Ma, Weihua Nong, Ou Zhong, Ke Liu, Siyuan Lei, Chen Wang, Xi Chen, Xiaocan Lei
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Ovarian Research
Subjects:
Nicotinamide mononucleotide
Premature ovarian insufficiency
Pyroptosis
Online Access:https://doi.org/10.1186/s13048-024-01534-w
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