Impact of non-high-density lipoprotein cholesterol in mortality and cardiovascular events among middle-aged Russian men: 40 years ago and now
Aim. To evaluate the non-high density lipoprotein cholesterol (non-HDL-C) predictive ability in relation to cardiovascular events, all-cause and cause-specific mortality and among middle-aged Russian men now and 40- years ago.Material and methods. For analysis data from 9507 men aged 35-64 without c...
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Столичная издательская компания
2024-12-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/3101 |
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| author | S. A. Shalnova A. E Imaeva Yu. A Balanova V. A Kutsenko A. V Kapustina V. A Metelskaya N. A Imaeva B. M Nazarov O. E Ivlev E. B Yarovaya O. M Drapkina |
| author_facet | S. A. Shalnova A. E Imaeva Yu. A Balanova V. A Kutsenko A. V Kapustina V. A Metelskaya N. A Imaeva B. M Nazarov O. E Ivlev E. B Yarovaya O. M Drapkina |
| author_sort | S. A. Shalnova |
| collection | DOAJ |
| description | Aim. To evaluate the non-high density lipoprotein cholesterol (non-HDL-C) predictive ability in relation to cardiovascular events, all-cause and cause-specific mortality and among middle-aged Russian men now and 40- years ago.Material and methods. For analysis data from 9507 men aged 35-64 without cardiovascular disease (CVD) who did not receive lipid-lowering therapy, participants of two independent population prospective cohort studies — 40-year retrospective (Russian LRC) and conducted at the present time (ESSE-RF) — were used. In the analysis, all-cause mortality, cancer and CVD mortality, and non-fatal CVD (myocardial infarction and STEMI stroke) were assessed. The follow-up period for the LRС study was 10 years, and for the ESSE-RF study, it was 7.8 years.Results. The mean value of non-HDL-C was 0.3 mmol/L higher among participants from the Russian LRC cohort than among men from the ESSE-RF cohort. Low non-HDL-C levels were associated with an increased risk of all-cause mortality. A strong link between high levels of non-HDL-C and the development of fatal and nonfatal CVD events was also found in both cohorts. Men with non-HDL-C levels ≥4.5 mmol/L in the LRC study and ≥4.2 mmol/L in the ESSE-RF study had a significantly increased risk of fatal and non-fatal CVDs (63% and 27%, respectively) and decreased risk of cancer mortality (28% and 50%, respectively). Conclusion. Downwards trends in non-HDL-C levels over the past 40 years were indicated. The study identified a decline of non-HDL-C in the general population level since the 1970s of the 20th century. Up to the present time, there is still a non-linear relationship between the level of non-HDL-C and total mortality, that could be explained by the presence of differently directed associations between this parameter, cancer mortality and the development of fatal and non-fatal CVDs. |
| format | Article |
| id | doaj-art-52ddcb238ab243a5b839e819fbaa4f11 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-52ddcb238ab243a5b839e819fbaa4f112025-08-23T10:00:37ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532024-12-0120549650510.20996/1819-6446-2024-31012234Impact of non-high-density lipoprotein cholesterol in mortality and cardiovascular events among middle-aged Russian men: 40 years ago and nowS. A. Shalnova0A. E Imaeva1Yu. A Balanova2V. A Kutsenko3A. V Kapustina4V. A Metelskaya5N. A Imaeva6B. M Nazarov7O. E Ivlev8E. B Yarovaya9O. M Drapkina10National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian FederationNational Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian FederationNational Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian FederationNational Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian FederationNational Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian FederationNational Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian FederationNational Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian FederationLLC «Healthy Family»National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian FederationNational Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian FederationNational Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian FederationAim. To evaluate the non-high density lipoprotein cholesterol (non-HDL-C) predictive ability in relation to cardiovascular events, all-cause and cause-specific mortality and among middle-aged Russian men now and 40- years ago.Material and methods. For analysis data from 9507 men aged 35-64 without cardiovascular disease (CVD) who did not receive lipid-lowering therapy, participants of two independent population prospective cohort studies — 40-year retrospective (Russian LRC) and conducted at the present time (ESSE-RF) — were used. In the analysis, all-cause mortality, cancer and CVD mortality, and non-fatal CVD (myocardial infarction and STEMI stroke) were assessed. The follow-up period for the LRС study was 10 years, and for the ESSE-RF study, it was 7.8 years.Results. The mean value of non-HDL-C was 0.3 mmol/L higher among participants from the Russian LRC cohort than among men from the ESSE-RF cohort. Low non-HDL-C levels were associated with an increased risk of all-cause mortality. A strong link between high levels of non-HDL-C and the development of fatal and nonfatal CVD events was also found in both cohorts. Men with non-HDL-C levels ≥4.5 mmol/L in the LRC study and ≥4.2 mmol/L in the ESSE-RF study had a significantly increased risk of fatal and non-fatal CVDs (63% and 27%, respectively) and decreased risk of cancer mortality (28% and 50%, respectively). Conclusion. Downwards trends in non-HDL-C levels over the past 40 years were indicated. The study identified a decline of non-HDL-C in the general population level since the 1970s of the 20th century. Up to the present time, there is still a non-linear relationship between the level of non-HDL-C and total mortality, that could be explained by the presence of differently directed associations between this parameter, cancer mortality and the development of fatal and non-fatal CVDs.https://www.rpcardio.online/jour/article/view/3101non-high-density lipoprotein cholesterolmendyslipidemiaall-cause mortalitycancer mortalitycardiovascular mortalitycardiovascular diseasescardiovascular events |
| spellingShingle | S. A. Shalnova A. E Imaeva Yu. A Balanova V. A Kutsenko A. V Kapustina V. A Metelskaya N. A Imaeva B. M Nazarov O. E Ivlev E. B Yarovaya O. M Drapkina Impact of non-high-density lipoprotein cholesterol in mortality and cardiovascular events among middle-aged Russian men: 40 years ago and now Рациональная фармакотерапия в кардиологии non-high-density lipoprotein cholesterol men dyslipidemia all-cause mortality cancer mortality cardiovascular mortality cardiovascular diseases cardiovascular events |
| title | Impact of non-high-density lipoprotein cholesterol in mortality and cardiovascular events among middle-aged Russian men: 40 years ago and now |
| title_full | Impact of non-high-density lipoprotein cholesterol in mortality and cardiovascular events among middle-aged Russian men: 40 years ago and now |
| title_fullStr | Impact of non-high-density lipoprotein cholesterol in mortality and cardiovascular events among middle-aged Russian men: 40 years ago and now |
| title_full_unstemmed | Impact of non-high-density lipoprotein cholesterol in mortality and cardiovascular events among middle-aged Russian men: 40 years ago and now |
| title_short | Impact of non-high-density lipoprotein cholesterol in mortality and cardiovascular events among middle-aged Russian men: 40 years ago and now |
| title_sort | impact of non high density lipoprotein cholesterol in mortality and cardiovascular events among middle aged russian men 40 years ago and now |
| topic | non-high-density lipoprotein cholesterol men dyslipidemia all-cause mortality cancer mortality cardiovascular mortality cardiovascular diseases cardiovascular events |
| url | https://www.rpcardio.online/jour/article/view/3101 |
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