Peniciisoquinoline A: A new tetrahydroisoquinoline from mangrove-derived fungus Penicillium sp. DM27
Objective: This study aims to search for structurally novel, natural bioactive products from mangrove-derived fungi. Methods: Compounds were isolated and purified by column chromatography on HP20 macroreticular resin, silica gel, Sephadex LH-20 gel, and high performance liquid chromatography. The st...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-09-01
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| Series: | Journal of Holistic Integrative Pharmacy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2707368823000468 |
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| author | Liming HE Zifang ZHAO Mengke ZHANG Zhijie XIANG Kui HONG Fengkai FAN Yousheng CAI |
| author_facet | Liming HE Zifang ZHAO Mengke ZHANG Zhijie XIANG Kui HONG Fengkai FAN Yousheng CAI |
| author_sort | Liming HE |
| collection | DOAJ |
| description | Objective: This study aims to search for structurally novel, natural bioactive products from mangrove-derived fungi. Methods: Compounds were isolated and purified by column chromatography on HP20 macroreticular resin, silica gel, Sephadex LH-20 gel, and high performance liquid chromatography. The structures of the isolates were analyzed using NMR and MS data, and the absolute configuration of 1 was determined by calculated ECD spectroscopic methods. The cytotoxicity of all the isolates was tested against HCT-116, HepG2, HEK 293t, and 5637 cancer cell lines using CCK-8 assay. Results: A new tetrahydroisoquinoline named peniciisoquinoline A (1) was obtained from Penicillium sp. DM27 along with five known compounds. Peniciisoquinoline A (1) was inactive against the four cancer cell lines. Conclusion: This study conducted chemical research on Penicillium sp. DM27 and tested the cytotoxic activity of the new alkaloid (1), which will assist in the further development and utilization of mangrove-derived fungi. |
| format | Article |
| id | doaj-art-52d84a97001b4d949cff53bf9be1c647 |
| institution | OA Journals |
| issn | 2707-3688 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Holistic Integrative Pharmacy |
| spelling | doaj-art-52d84a97001b4d949cff53bf9be1c6472025-08-20T02:14:03ZengKeAi Communications Co., Ltd.Journal of Holistic Integrative Pharmacy2707-36882022-09-013324825410.1016/S2707-3688(23)00046-8Peniciisoquinoline A: A new tetrahydroisoquinoline from mangrove-derived fungus Penicillium sp. DM27Liming HE0Zifang ZHAO1Mengke ZHANG2Zhijie XIANG3Kui HONG4Fengkai FAN5Yousheng CAI6Hubei Key Laboratory of Purification and Application of Plant Anti-Cancer Ingredients, College of Chemistry and Life Science, Hubei University of Education, Wuhan 430205, China; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, ChinaKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, ChinaDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaWuhan Polytechnic University, School of Life Science and Technology, Wuhan 430023, ChinaKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, ChinaHubei Key Laboratory of Purification and Application of Plant Anti-Cancer Ingredients, College of Chemistry and Life Science, Hubei University of Education, Wuhan 430205, China; Corresponding authorsKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; Corresponding authorsObjective: This study aims to search for structurally novel, natural bioactive products from mangrove-derived fungi. Methods: Compounds were isolated and purified by column chromatography on HP20 macroreticular resin, silica gel, Sephadex LH-20 gel, and high performance liquid chromatography. The structures of the isolates were analyzed using NMR and MS data, and the absolute configuration of 1 was determined by calculated ECD spectroscopic methods. The cytotoxicity of all the isolates was tested against HCT-116, HepG2, HEK 293t, and 5637 cancer cell lines using CCK-8 assay. Results: A new tetrahydroisoquinoline named peniciisoquinoline A (1) was obtained from Penicillium sp. DM27 along with five known compounds. Peniciisoquinoline A (1) was inactive against the four cancer cell lines. Conclusion: This study conducted chemical research on Penicillium sp. DM27 and tested the cytotoxic activity of the new alkaloid (1), which will assist in the further development and utilization of mangrove-derived fungi.http://www.sciencedirect.com/science/article/pii/S2707368823000468Penicillium sp.TetrahydroisoquinolineCytotoxicity |
| spellingShingle | Liming HE Zifang ZHAO Mengke ZHANG Zhijie XIANG Kui HONG Fengkai FAN Yousheng CAI Peniciisoquinoline A: A new tetrahydroisoquinoline from mangrove-derived fungus Penicillium sp. DM27 Journal of Holistic Integrative Pharmacy Penicillium sp. Tetrahydroisoquinoline Cytotoxicity |
| title | Peniciisoquinoline A: A new tetrahydroisoquinoline from mangrove-derived fungus Penicillium sp. DM27 |
| title_full | Peniciisoquinoline A: A new tetrahydroisoquinoline from mangrove-derived fungus Penicillium sp. DM27 |
| title_fullStr | Peniciisoquinoline A: A new tetrahydroisoquinoline from mangrove-derived fungus Penicillium sp. DM27 |
| title_full_unstemmed | Peniciisoquinoline A: A new tetrahydroisoquinoline from mangrove-derived fungus Penicillium sp. DM27 |
| title_short | Peniciisoquinoline A: A new tetrahydroisoquinoline from mangrove-derived fungus Penicillium sp. DM27 |
| title_sort | peniciisoquinoline a a new tetrahydroisoquinoline from mangrove derived fungus penicillium sp dm27 |
| topic | Penicillium sp. Tetrahydroisoquinoline Cytotoxicity |
| url | http://www.sciencedirect.com/science/article/pii/S2707368823000468 |
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