Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship
The interaction between human cytomegalovirus (HCMV) and its host is a complex process that begins with viral attachment and entry into host cells, culminating in the development of a specific adaptive response that clears the acute infection but fails to eradicate HCMV. We review the viral and cell...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/607276 |
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| author | Giada Rossini Cristina Cerboni Angela Santoni Maria Paola Landini Santo Landolfo Deborah Gatti Giorgio Gribaudo Stefania Varani |
| author_facet | Giada Rossini Cristina Cerboni Angela Santoni Maria Paola Landini Santo Landolfo Deborah Gatti Giorgio Gribaudo Stefania Varani |
| author_sort | Giada Rossini |
| collection | DOAJ |
| description | The interaction between human cytomegalovirus (HCMV) and its host is a complex process that begins with viral attachment and entry into host cells, culminating in the development of a specific adaptive response that clears the acute infection but fails to eradicate HCMV. We review the viral and cellular partners that mediate early host responses to HCMV with regard to the interaction between structural components of virions (viral glycoproteins) and cellular receptors (attachment/entry receptors, toll-like receptors, and other nucleic acid sensors) or intrinsic factors (PML, hDaxx, Sp100, viperin, interferon inducible protein 16), the reactions of innate immune cells (antigen presenting cells and natural killer cells), the numerous mechanisms of viral immunoevasion, and the potential exploitation of events that are associated with early phases of virus-host interplay as a therapeutic strategy. |
| format | Article |
| id | doaj-art-52d6c3d53bcd497d930366516c1482ff |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-52d6c3d53bcd497d930366516c1482ff2025-08-20T02:05:12ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/607276607276Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional RelationshipGiada Rossini0Cristina Cerboni1Angela Santoni2Maria Paola Landini3Santo Landolfo4Deborah Gatti5Giorgio Gribaudo6Stefania Varani7Section of Microbiology, Department of Hematology and Oncology “L. & A. Seragnoli”, University of Bologna, 40138 Bologna, ItalyDepartment of Molecular Medicine, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, ItalyDepartment of Molecular Medicine, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, ItalySection of Microbiology, Department of Hematology and Oncology “L. & A. Seragnoli”, University of Bologna, 40138 Bologna, ItalyDepartment of Public Health and Microbiology, University of Turin, Turin, ItalyDepartment of Public Health and Microbiology, University of Turin, Turin, ItalyDepartment of Public Health and Microbiology, University of Turin, Turin, ItalySection of Microbiology, Department of Hematology and Oncology “L. & A. Seragnoli”, University of Bologna, 40138 Bologna, ItalyThe interaction between human cytomegalovirus (HCMV) and its host is a complex process that begins with viral attachment and entry into host cells, culminating in the development of a specific adaptive response that clears the acute infection but fails to eradicate HCMV. We review the viral and cellular partners that mediate early host responses to HCMV with regard to the interaction between structural components of virions (viral glycoproteins) and cellular receptors (attachment/entry receptors, toll-like receptors, and other nucleic acid sensors) or intrinsic factors (PML, hDaxx, Sp100, viperin, interferon inducible protein 16), the reactions of innate immune cells (antigen presenting cells and natural killer cells), the numerous mechanisms of viral immunoevasion, and the potential exploitation of events that are associated with early phases of virus-host interplay as a therapeutic strategy.http://dx.doi.org/10.1155/2012/607276 |
| spellingShingle | Giada Rossini Cristina Cerboni Angela Santoni Maria Paola Landini Santo Landolfo Deborah Gatti Giorgio Gribaudo Stefania Varani Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship Mediators of Inflammation |
| title | Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship |
| title_full | Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship |
| title_fullStr | Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship |
| title_full_unstemmed | Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship |
| title_short | Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship |
| title_sort | interplay between human cytomegalovirus and intrinsic innate host responses a complex bidirectional relationship |
| url | http://dx.doi.org/10.1155/2012/607276 |
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