Direct Incorporation of [11C]CO2 into Asymmetric [11C]Carbonates
A novel carbon-11 radiolabelling methodology for the synthesis of the dialkylcarbonate functional group has been developed. The method uses cyclotron-produced short-lived [11C]CO2 (half-life 20.4 min) directly from the cyclotron target in a one-pot synthesis. Alcohol in the presence of base trapped...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2018/7641304 |
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| author | Abdul Karim Haji Dheere Salvatore Bongarzone Dinah Shakir Antony Gee |
| author_facet | Abdul Karim Haji Dheere Salvatore Bongarzone Dinah Shakir Antony Gee |
| author_sort | Abdul Karim Haji Dheere |
| collection | DOAJ |
| description | A novel carbon-11 radiolabelling methodology for the synthesis of the dialkylcarbonate functional group has been developed. The method uses cyclotron-produced short-lived [11C]CO2 (half-life 20.4 min) directly from the cyclotron target in a one-pot synthesis. Alcohol in the presence of base trapped [11C]CO2 efficiently forming an [11C]alkylcarbonate intermediate that subsequently reacted with an alkylchloride producing the di-substituted [11C]carbonate (34% radiochemical yield, determined by radio-HPLC) in 5 minutes from the end of [11C]CO2 cyclotron delivery. |
| format | Article |
| id | doaj-art-52ca8f84d35d4d0eaed2add6ee33b979 |
| institution | OA Journals |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-52ca8f84d35d4d0eaed2add6ee33b9792025-08-20T02:05:11ZengWileyJournal of Chemistry2090-90632090-90712018-01-01201810.1155/2018/76413047641304Direct Incorporation of [11C]CO2 into Asymmetric [11C]CarbonatesAbdul Karim Haji Dheere0Salvatore Bongarzone1Dinah Shakir2Antony Gee3Department of Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King’s College London, King’s Health Partners, St. Thomas’ Hospital, London, UKDepartment of Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King’s College London, King’s Health Partners, St. Thomas’ Hospital, London, UKDepartment of Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King’s College London, King’s Health Partners, St. Thomas’ Hospital, London, UKDepartment of Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King’s College London, King’s Health Partners, St. Thomas’ Hospital, London, UKA novel carbon-11 radiolabelling methodology for the synthesis of the dialkylcarbonate functional group has been developed. The method uses cyclotron-produced short-lived [11C]CO2 (half-life 20.4 min) directly from the cyclotron target in a one-pot synthesis. Alcohol in the presence of base trapped [11C]CO2 efficiently forming an [11C]alkylcarbonate intermediate that subsequently reacted with an alkylchloride producing the di-substituted [11C]carbonate (34% radiochemical yield, determined by radio-HPLC) in 5 minutes from the end of [11C]CO2 cyclotron delivery.http://dx.doi.org/10.1155/2018/7641304 |
| spellingShingle | Abdul Karim Haji Dheere Salvatore Bongarzone Dinah Shakir Antony Gee Direct Incorporation of [11C]CO2 into Asymmetric [11C]Carbonates Journal of Chemistry |
| title | Direct Incorporation of [11C]CO2 into Asymmetric [11C]Carbonates |
| title_full | Direct Incorporation of [11C]CO2 into Asymmetric [11C]Carbonates |
| title_fullStr | Direct Incorporation of [11C]CO2 into Asymmetric [11C]Carbonates |
| title_full_unstemmed | Direct Incorporation of [11C]CO2 into Asymmetric [11C]Carbonates |
| title_short | Direct Incorporation of [11C]CO2 into Asymmetric [11C]Carbonates |
| title_sort | direct incorporation of 11c co2 into asymmetric 11c carbonates |
| url | http://dx.doi.org/10.1155/2018/7641304 |
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