Claudin 18 (43–14A clone) expression in pancreatic ductal adenocarcinoma: Assessment of a potential clinical biomarker for zolbetuximab therapy

Claudin 18 (43–14A clone) expression in pancreatic ductal adenocarcinoma: Assessment of a potential clinical biomarker for zolbetuximab therapy

Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal, with a five-year survival rate below 15 %. Claudin 18.2 (CLDN18.2) has emerged as a novel potential therapeutic target in PDAC. Zolbetuximab, a monoclonal antibody targeting CLDN18.2, has demonstrated therapeutic benefit in gastric cance...

Full description

Saved in:

Bibliographic Details
Main Authors:	Riley J. Arseneau, Emma Kempster, Carley Bekkers, Thomas Samson, Boris L. Gala-Lopez, Ravi Ramjeesingh, Jeanette E. Boudreau, Thomas Arnason
Format:	Article
Language:	English
Published:	Elsevier 2025-05-01
Series:	Translational Oncology
Subjects:	Pancreatic ductal carcinoma Immunohistochemistry Claudin 18 protein, human Biomarkers 43–14a zolbetuximab
Online Access:	http://www.sciencedirect.com/science/article/pii/S1936523325000932
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Consensus guidance for prevention and management of nausea and vomiting in patients treated with zolbetuximab + chemotherapy: a RAND/UCLA modified Delphi panel study
by: S.J. Klempner, et al.
Published: (2025-03-01)

The expression of the tight junction protein and therapeutical target Claudin 18.2 is heterogeneously distributed within esophageal and gastric adenocarcinoma
by: Svetlana Pak, et al.
Published: (2025-08-01)

Case Report: Zolbetuximab-induced gastritis with protein-losing gastroenteropathy and hypogammaglobulinemia: a case implicating IgA vasculitis
by: Yasuhiro Mitsui, et al.
Published: (2025-07-01)

The Impacts of Simulated Microgravity on The Cell Viability and Claudin-1 and Claudin-3 Expression of MCF-7 Breast Cancer Cells
by: Margrita Adamian, et al.
Published: (2021-05-01)

Features of expression of protein Claudin 11 at various forms of male infertility
by: S. V. Bazalytska, et al.
Published: (2012-12-01)

The research trends and hotspots of claudins in the field of cancer
by: Weixin Jing, et al.
Published: (2025-12-01)

Tight junctional protein family, Claudins in cancer and cancer metastasis
by: Wenxiao Ji, et al.
Published: (2025-07-01)

Quarante ans après. En hommage à Claudine Gothot-Mersch
by: Françoise Gaillard
Published: (2018-12-01)

Claudins in genitourinary tract neoplasms: mechanisms, prognosis, and therapeutic prospects
by: Tarek Ziad Arabi, et al.
Published: (2023-12-01)

Rho-ROCK liberates sequestered claudin for rapid de novo tight junction formation
by: Yuma Cho, et al.
Published: (2025-07-01)

Claudin 4 in pancreatic β cells is involved in regulating the functional state of adult islets
by: Hongtu Li, et al.
Published: (2020-01-01)

HDAC3 regulates the diurnal rhythms of claudin expression and intestinal permeability
by: Hunter Christopher, et al.
Published: (2024-11-01)

Cloning of claudin-5 Gene from Oreochromis niloticus and Analysis of Its Expression Under Streptococcus agalactiae
by: Yanghui CHEN, et al.
Published: (2024-07-01)

Predictive model of small vessel vascular dementia based on comorbidities, cytokines and claudin-1 genetic polymorphisms
by: Joel Cassar, et al.
Published: (2025-01-01)

Development and Characterization of 4A7: A High-Affinity Monoclonal Antibody Targeting Claudin18.2
by: Wu Y, et al.
Published: (2025-03-01)

Role of HEG1 and Claudin-4 Immunohistochemistry in the Differential Diagnosis of Lung Adenocarcinoma from Malignant Mesothelioma in Pleural Effusion Cytology
by: Aziza E. ABDELRAHMAN, et al.
Published: (2025-05-01)

Claudin-11, a hypomyelinating leukodystrophy 22 (HLD22)-responsible protein, uniquely interacts with shroom-2 to change cell phenotypes
by: Sakurako Kobayashi, et al.
Published: (2025-01-01)

Tirzepatide mitigates Stroke-Induced Blood-Brain barrier disruption by modulating Claudin-1 and C/EBP-α pathways
by: Duozi Wang, et al.
Published: (2025-07-01)

Clinical and laboratory significance of soluble claudin-5 and VEGF in ovarian cancer
by: N. E. Kushlinskii, et al.
Published: (2025-04-01)

Possible Roles of Micro RNA‑142‑5p and Claudin-1 in Development of Hashimoto’s Thyroiditis in Iraqi Patients
by: Khaled Nather Taha, et al.
Published: (2022-06-01)

Biochemical Modulators of Tight Junctions (TJs): Occludin, Claudin-2 and Zonulin as Biomarkers of Intestinal Barrier Leakage in the Diagnosis and Assessment of Inflammatory Bowel Disease Progression
by: Aleksandra Górecka, et al.
Published: (2024-09-01)

Long-term expansion of basal cells and the novel differentiation methods identify mechanisms for switching Claudin expression in normal epithelia
by: Akihito Inoko, et al.
Published: (2025-04-01)

Calcium sensing receptor regulate claudin-14 via PKA-STAT3 pathway in rat model of nephrolithiasis
by: Peiyue Luo, et al.
Published: (2024-12-01)

Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression
by: Yuta Maetani, et al.
Published: (2025-07-01)

Transformação v. 43, n. 1, 2020
by: Equipe Editorial
Published: (2020-03-01)

Association of clinico-pathological and immunohistochemical prognostic parameters with presence of ductal carcinoma in-situ in an invasive ductal carcinoma of breast
by: Dhivya Balaiya, et al.
Published: (2023-12-01)

Laparoscopic curative resection following perioperative chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel and its influence on Claudin18.2 expression in advanced gastric or gastroesophageal junction adenocarcinoma: a two-case report
by: Tohru Takahashi, et al.
Published: (2025-04-01)

DIFFICULTIES OF DIAGNOSTICS AND CHOICE OF SURGICAL APPROACH IN PATIENTS WITH DUCTAL CHOLANGIOCARCINOMA
by: D. A. Granov, et al.
Published: (2017-02-01)

Rutin ameliorates stress–induced blood‒brain barrier dysfunction and cognitive decline via the endothelial HDAC1‒Claudin–5 axis
by: Zhao–Wei Sun, et al.
Published: (2025-04-01)

Downregulation of connexin 43 is crucial for basal cell alignment in ameloblastoma and odontogenic keratocyst
by: Ahmed Abdelaziz Mohamed Essa
Published: (2024-07-01)

Contribution of gut microbiome to pancreatic ductal adenocarcinoma development
by: D. V. Zaitsev, et al.
Published: (2025-05-01)

Single vein resection in surgery for pancreatic ductal carcinoma as a criterion of resectability
by: D. A. Chichevatov, et al.
Published: (2022-09-01)

Immunohistochemical Evaluation of the Tumor Immune Microenvironment in Pancreatic Ductal Adenocarcinoma
by: Gelu Mihai Breaza, et al.
Published: (2025-03-01)

Endometriotic Follicular Fluid Affects Granulosa Cells’ Morphology and Increases Duplication Rate and Connexin-43 Expression
by: Loris Marin, et al.
Published: (2025-04-01)

Experimental and numerical evaluation of REGUPOL E43 mechanical and ballistic properties
by: Eugen Trana, et al.
Published: (2025-07-01)

Myocardial expression of connexin 43 in cats with hypertrophic and restrictive cardiomyopathy phenotype
by: Dmitrij Oleynikov
Published: (2025-03-01)

Genomic features of liquid biopsies from patients with prostate cancer with and without ductal adenocarcinoma
by: Qiyu Zhu, et al.
Published: (2025-05-01)

HOXA9 and CD163 potentiate pancreatic ductal adenocarcinoma progression
by: Aiat Shaban Hemida, et al.
Published: (2024-10-01)

Exploration of the breast ductal carcinoma in situ signature and its prognostic implications
by: Jiao Zhang, et al.
Published: (2023-02-01)

Connexin 43 is downregulated in advanced Parkinson’s disease in multiple brain regions which correlates with symptoms
by: Nataly Hastings, et al.
Published: (2025-03-01)