Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology.

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology.

<h4>Background</h4>The von Hippel-Lindau tumour suppressor protein-hypoxia-inducible factor (VHL-HIF) pathway has attracted widespread medical interest as a transcriptional system controlling cellular responses to hypoxia, yet insights into its role in systemic human physiology remain li...

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Main Authors: Thomas G Smith, Jerome T Brooks, George M Balanos, Terence R Lappin, D Mark Layton, Dawn L Leedham, Chun Liu, Patrick H Maxwell, Mary F McMullin, Christopher J McNamara, Melanie J Percy, Christopher W Pugh, Peter J Ratcliffe, Nick P Talbot, Marilyn Treacy, Peter A Robbins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-07-01
Series:PLoS Medicine
Online Access:https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0030290&type=printable
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