Inhibition of hypoxic exosomal miR-423-3p decreases glioma progression by restricting autophagy in astrocytes

Inhibition of hypoxic exosomal miR-423-3p decreases glioma progression by restricting autophagy in astrocytes

Abstract The tumor microenvironment (TME) of gliomas comprises glioma cells and surrounding cells, such as astrocytes, macrophages, T cells, and neurons. In the TME, glioma cells can activate normal human astrocytes (NHAs) through the secretion of exosomes and the activation of astrocytes can furthe...

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Bibliographic Details
Main Authors: Ziyi Tang, Zhiwei Xue, Xuchen Liu, Yan Zhang, Jiangli Zhao, Junzhi Liu, Lin Zhang, Qindong Guo, Bowen Feng, Jiwei Wang, Di Zhang, Xingang Li
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07576-2
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