Roles of microRNAs in multiple organs under mycotoxin stress by bioinformatic analysis
Mycotoxins are naturally produced by certain fungi and are common food contaminants that endanger human health and well-being worldwide. They have broad implications, including roles in carcinogenesis, which is often fatal. Therefore, identifying new biomarkers of mycotoxin activity and enabling ear...
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| Language: | English |
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Elsevier
2025-11-01
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| Series: | Poultry Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579125009009 |
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| author | Eun Jung Sohn Kun-Taek Park |
| author_facet | Eun Jung Sohn Kun-Taek Park |
| author_sort | Eun Jung Sohn |
| collection | DOAJ |
| description | Mycotoxins are naturally produced by certain fungi and are common food contaminants that endanger human health and well-being worldwide. They have broad implications, including roles in carcinogenesis, which is often fatal. Therefore, identifying new biomarkers of mycotoxin activity and enabling early diagnosis of mycotoxin-induced diseases is critical. MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression and influence different physiological processes, including those involved in heart disease, cancer, and apoptosis. Furthermore, miRNAs are often involved in mycotoxin-induced toxicity and respond to various environmental factors. In this review, we discuss the miRNAs altered in response to important mycotoxins in several organisms, with a focus on the predicted biological roles and targets of miRNAs regulated by two common mycotoxins: aflatoxin B1 and ochratoxin A. This review aims to serve as a resource for researchers and scientists working to understand the molecular mechanisms underlying mycotoxin toxicity and developing targeted interventions to prevent and control mycotoxin-induced damage to various organs. |
| format | Article |
| id | doaj-art-52c5f6825e814dc49c42cd4cdc21280b |
| institution | Kabale University |
| issn | 0032-5791 |
| language | English |
| publishDate | 2025-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj-art-52c5f6825e814dc49c42cd4cdc21280b2025-08-22T04:54:40ZengElsevierPoultry Science0032-57912025-11-011041110565910.1016/j.psj.2025.105659Roles of microRNAs in multiple organs under mycotoxin stress by bioinformatic analysisEun Jung Sohn0Kun-Taek Park1Department of Biotechnology, Inje University, 197 Inje-ro, Gimhae 50834, South Korea; Department of SmartBio, Kyungsung University, Busan 48434, South Korea; Department of Biopharmaceutical Engineering, Dongguk University-WISE, Gyeongju 38066, South KoreaDepartment of Biotechnology, Inje University, 197 Inje-ro, Gimhae 50834, South Korea; Corresponding authors at: Department of Biotechnology, Inje University, 197 Inje-ro, Gimhae 50834, South Korea.Mycotoxins are naturally produced by certain fungi and are common food contaminants that endanger human health and well-being worldwide. They have broad implications, including roles in carcinogenesis, which is often fatal. Therefore, identifying new biomarkers of mycotoxin activity and enabling early diagnosis of mycotoxin-induced diseases is critical. MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression and influence different physiological processes, including those involved in heart disease, cancer, and apoptosis. Furthermore, miRNAs are often involved in mycotoxin-induced toxicity and respond to various environmental factors. In this review, we discuss the miRNAs altered in response to important mycotoxins in several organisms, with a focus on the predicted biological roles and targets of miRNAs regulated by two common mycotoxins: aflatoxin B1 and ochratoxin A. This review aims to serve as a resource for researchers and scientists working to understand the molecular mechanisms underlying mycotoxin toxicity and developing targeted interventions to prevent and control mycotoxin-induced damage to various organs.http://www.sciencedirect.com/science/article/pii/S0032579125009009MycotoxinsMicroRNAsOrgan damageAflatoxin B1 and ochratoxin ALivestock damage |
| spellingShingle | Eun Jung Sohn Kun-Taek Park Roles of microRNAs in multiple organs under mycotoxin stress by bioinformatic analysis Poultry Science Mycotoxins MicroRNAs Organ damage Aflatoxin B1 and ochratoxin A Livestock damage |
| title | Roles of microRNAs in multiple organs under mycotoxin stress by bioinformatic analysis |
| title_full | Roles of microRNAs in multiple organs under mycotoxin stress by bioinformatic analysis |
| title_fullStr | Roles of microRNAs in multiple organs under mycotoxin stress by bioinformatic analysis |
| title_full_unstemmed | Roles of microRNAs in multiple organs under mycotoxin stress by bioinformatic analysis |
| title_short | Roles of microRNAs in multiple organs under mycotoxin stress by bioinformatic analysis |
| title_sort | roles of micrornas in multiple organs under mycotoxin stress by bioinformatic analysis |
| topic | Mycotoxins MicroRNAs Organ damage Aflatoxin B1 and ochratoxin A Livestock damage |
| url | http://www.sciencedirect.com/science/article/pii/S0032579125009009 |
| work_keys_str_mv | AT eunjungsohn rolesofmicrornasinmultipleorgansundermycotoxinstressbybioinformaticanalysis AT kuntaekpark rolesofmicrornasinmultipleorgansundermycotoxinstressbybioinformaticanalysis |