The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature
Introduction and objectives Surgical site infections (SSIs) represent a common and serious complication of all surgical interventions. Microorganisms are able to colonise sutures that are implanted in the skin, which is a causative factor of SSIs. Triclosan-coated sutures are antibacterial sutures a...
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BMJ Publishing Group
2019-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/9/e029727.full |
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| author | Imran Ahmed Adam Jonathan Boulton Sana Rizvi William Carlos Edward Dickenson NA Smith Mike Reed |
| author_facet | Imran Ahmed Adam Jonathan Boulton Sana Rizvi William Carlos Edward Dickenson NA Smith Mike Reed |
| author_sort | Imran Ahmed |
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| description | Introduction and objectives Surgical site infections (SSIs) represent a common and serious complication of all surgical interventions. Microorganisms are able to colonise sutures that are implanted in the skin, which is a causative factor of SSIs. Triclosan-coated sutures are antibacterial sutures aimed at reducing SSIs. Our objective is to update the existing literature by systematically reviewing available evidence to assess the effectiveness of triclosan-coated sutures in the prevention of SSIs.Methods A systematic review of EMBASE, MEDLINE, AMED (Allied and complementary medicine database) and CENTRAL was performed to identify full text randomised controlled trials (RCTs) on 31 May 2019.Intervention Triclosan-coated sutures versus non-triclosan-coated sutures.Primary outcome Our primary outcome was the development of SSIs at 30 days postoperatively. A meta-analysis was performed using a fixed-effects model.Results Twenty-five RCTs were included involving 11 957 participants. Triclosan-coated sutures were used in 6008 participants and non triclosan-coated sutures were used in 5949. Triclosan-coated sutures significantly reduced the risk of SSIs at 30 days (relative risk 0.73, 95% CI 0.65 to 0.82). Further sensitivity analysis demonstrated that triclosan-coated sutures significantly reduced the risk of SSIs in both clean and contaminated surgery.Conclusion Triclosan-coated sutures have been shown to significantly reduced the risk of SSIs when compared with standard sutures. This is in agreement with previous work in this area. This study represented the largest review to date in this area. This moderate quality evidence recommends the use of triclosan-coated sutures in order to reduce the risk of SSIs particularly in clean and contaminated surgical procedures.PROSPERO registration number CRD42014014856 |
| format | Article |
| id | doaj-art-52c30bca2c1e4d69becd773d149df3a7 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-52c30bca2c1e4d69becd773d149df3a72025-08-20T01:50:39ZengBMJ Publishing GroupBMJ Open2044-60552019-09-019910.1136/bmjopen-2019-029727The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literatureImran Ahmed0Adam Jonathan Boulton1Sana Rizvi2William Carlos3Edward Dickenson4NA Smith5Mike Reed6Centre of Excellence in Women and Child Health, Aga Khan University, Karachi, PakistanWarwick Medical School, University of Warwick, Coventry, UK2 Trauma and Orthopaedics, University Hospital Coventry, Coventry, UK2 Trauma and Orthopaedics, University Hospital Coventry, Coventry, UK3 Warwick Medical School, University of Warwick, Coventry, UK3 University Hospitals Coventry and Warwickshire, Coventry, UKNorthumbria Healthcare NHS Foundation Trust, North Shields, UKIntroduction and objectives Surgical site infections (SSIs) represent a common and serious complication of all surgical interventions. Microorganisms are able to colonise sutures that are implanted in the skin, which is a causative factor of SSIs. Triclosan-coated sutures are antibacterial sutures aimed at reducing SSIs. Our objective is to update the existing literature by systematically reviewing available evidence to assess the effectiveness of triclosan-coated sutures in the prevention of SSIs.Methods A systematic review of EMBASE, MEDLINE, AMED (Allied and complementary medicine database) and CENTRAL was performed to identify full text randomised controlled trials (RCTs) on 31 May 2019.Intervention Triclosan-coated sutures versus non-triclosan-coated sutures.Primary outcome Our primary outcome was the development of SSIs at 30 days postoperatively. A meta-analysis was performed using a fixed-effects model.Results Twenty-five RCTs were included involving 11 957 participants. Triclosan-coated sutures were used in 6008 participants and non triclosan-coated sutures were used in 5949. Triclosan-coated sutures significantly reduced the risk of SSIs at 30 days (relative risk 0.73, 95% CI 0.65 to 0.82). Further sensitivity analysis demonstrated that triclosan-coated sutures significantly reduced the risk of SSIs in both clean and contaminated surgery.Conclusion Triclosan-coated sutures have been shown to significantly reduced the risk of SSIs when compared with standard sutures. This is in agreement with previous work in this area. This study represented the largest review to date in this area. This moderate quality evidence recommends the use of triclosan-coated sutures in order to reduce the risk of SSIs particularly in clean and contaminated surgical procedures.PROSPERO registration number CRD42014014856https://bmjopen.bmj.com/content/9/9/e029727.full |
| spellingShingle | Imran Ahmed Adam Jonathan Boulton Sana Rizvi William Carlos Edward Dickenson NA Smith Mike Reed The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature BMJ Open |
| title | The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature |
| title_full | The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature |
| title_fullStr | The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature |
| title_full_unstemmed | The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature |
| title_short | The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature |
| title_sort | use of triclosan coated sutures to prevent surgical site infections a systematic review and meta analysis of the literature |
| url | https://bmjopen.bmj.com/content/9/9/e029727.full |
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