Preterm Neonates with Respiratory Distress Syndrome: Ventilator-Induced Lung Injury and Oxidative Stress
Ventilator-induced lung injury is well recognized, and appropriate arterial saturation target is unknown, so gentle modes of ventilation and minimizing oxidative stress have been well studied. Our objective was to analyze any association between the oxygen levels at blood sampling and plasma levels...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/6963754 |
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| author | Clarissa Gutiérrez Carvalho Renato Soibelmann Procianoy Eurico Camargo Neto Rita C. Silveira |
| author_facet | Clarissa Gutiérrez Carvalho Renato Soibelmann Procianoy Eurico Camargo Neto Rita C. Silveira |
| author_sort | Clarissa Gutiérrez Carvalho |
| collection | DOAJ |
| description | Ventilator-induced lung injury is well recognized, and appropriate arterial saturation target is unknown, so gentle modes of ventilation and minimizing oxidative stress have been well studied. Our objective was to analyze any association between the oxygen levels at blood sampling and plasma levels of the interleukins IL-6, IL-1β, IL-10, and IL-8 and TNF-α in preterm newborns under mechanical ventilation (MV) in their first two days. Methods. Prospective cohort including neonates with severe respiratory distress. Blood samples were collected right before and 2 hours after invasive MV. For analysis purposes, newborns were separated according to oxygen requirement: low oxygen (≤30%) and high oxygen (>30%) groups. Interleukins were measured using a commercially available kit. Results. 20 neonates (gestational age 32.2 ± 3 weeks) were evaluated. Median O2 saturation levels pre-MV were not different in both oxygen groups. In the high oxygen group, IL-6, IL-8, and TNF-α plasma levels increased significantly after two hours under MV. Conclusions. Despite the small sample studied, data showed that there is a relationship between VILI, proinflammatory cytokines, and oxygen-induced lung injury, but a study considering oxidative marker measurements is needed. It seems that less oxygen may keep safer saturation targets playing a less harmful role. |
| format | Article |
| id | doaj-art-52c1d8fd2e2d4c7a8afcba7847ad20e1 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-52c1d8fd2e2d4c7a8afcba7847ad20e12025-02-03T01:09:24ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/69637546963754Preterm Neonates with Respiratory Distress Syndrome: Ventilator-Induced Lung Injury and Oxidative StressClarissa Gutiérrez Carvalho0Renato Soibelmann Procianoy1Eurico Camargo Neto2Rita C. Silveira3Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilDepartment of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilDepartment of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilDepartment of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilVentilator-induced lung injury is well recognized, and appropriate arterial saturation target is unknown, so gentle modes of ventilation and minimizing oxidative stress have been well studied. Our objective was to analyze any association between the oxygen levels at blood sampling and plasma levels of the interleukins IL-6, IL-1β, IL-10, and IL-8 and TNF-α in preterm newborns under mechanical ventilation (MV) in their first two days. Methods. Prospective cohort including neonates with severe respiratory distress. Blood samples were collected right before and 2 hours after invasive MV. For analysis purposes, newborns were separated according to oxygen requirement: low oxygen (≤30%) and high oxygen (>30%) groups. Interleukins were measured using a commercially available kit. Results. 20 neonates (gestational age 32.2 ± 3 weeks) were evaluated. Median O2 saturation levels pre-MV were not different in both oxygen groups. In the high oxygen group, IL-6, IL-8, and TNF-α plasma levels increased significantly after two hours under MV. Conclusions. Despite the small sample studied, data showed that there is a relationship between VILI, proinflammatory cytokines, and oxygen-induced lung injury, but a study considering oxidative marker measurements is needed. It seems that less oxygen may keep safer saturation targets playing a less harmful role.http://dx.doi.org/10.1155/2018/6963754 |
| spellingShingle | Clarissa Gutiérrez Carvalho Renato Soibelmann Procianoy Eurico Camargo Neto Rita C. Silveira Preterm Neonates with Respiratory Distress Syndrome: Ventilator-Induced Lung Injury and Oxidative Stress Journal of Immunology Research |
| title | Preterm Neonates with Respiratory Distress Syndrome: Ventilator-Induced Lung Injury and Oxidative Stress |
| title_full | Preterm Neonates with Respiratory Distress Syndrome: Ventilator-Induced Lung Injury and Oxidative Stress |
| title_fullStr | Preterm Neonates with Respiratory Distress Syndrome: Ventilator-Induced Lung Injury and Oxidative Stress |
| title_full_unstemmed | Preterm Neonates with Respiratory Distress Syndrome: Ventilator-Induced Lung Injury and Oxidative Stress |
| title_short | Preterm Neonates with Respiratory Distress Syndrome: Ventilator-Induced Lung Injury and Oxidative Stress |
| title_sort | preterm neonates with respiratory distress syndrome ventilator induced lung injury and oxidative stress |
| url | http://dx.doi.org/10.1155/2018/6963754 |
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