Single-cell transcriptome and multi-omics integration reveal ferroptosis-driven immune microenvironment remodeling in knee osteoarthritis

Single-cell transcriptome and multi-omics integration reveal ferroptosis-driven immune microenvironment remodeling in knee osteoarthritis

BackgroundKnee osteoarthritis (KOA) is a chronic inflammatory joint disorder marked by cartilage degradation and immune microenvironment dysregulation. While transcriptomic studies have identified key pathways in KOA, the interplay between ferroptosis (an iron-dependent cell death mechanism) and imm...

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Bibliographic Details
Main Authors: Yushun Wu, Jing Liu, Wenying Yu, Xiaoding Wang, Jian Li, Weiquan Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
knee osteoarthritis
ferroptosis
single-cell transcriptomics
immune microenvironment
diagnostic biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1608378/full
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