Therapeutic role of fluconazole in immunocompetent patients with pulmonary cryptococcosis: A case report
The present investigation examines the potential for customized treatment of pulmonary cryptococcosis using fluconazole in an immunocompetent individual. Therapeutic drug monitoring (TDM) was utilized throughout treatment to assess fluconazole levels. Research indicated that the MIC90 for cryptococc...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | IDCases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250925000435 |
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| author | Huimin Yu Shuang Hua Qifei Sha Tang Tang Yuzhu Cao |
| author_facet | Huimin Yu Shuang Hua Qifei Sha Tang Tang Yuzhu Cao |
| author_sort | Huimin Yu |
| collection | DOAJ |
| description | The present investigation examines the potential for customized treatment of pulmonary cryptococcosis using fluconazole in an immunocompetent individual. Therapeutic drug monitoring (TDM) was utilized throughout treatment to assess fluconazole levels. Research indicated that the MIC90 for cryptococcus in China is around 8 mg/L. We evaluated the area under the curve (AUC) relative to the minimal inhibitory concentration (MIC), focusing on the AUC from 0 to 24 h (AUC0–24 h/MIC). Fluconazole's dosage was adjusted according to pharmacokinetics/pharmacodynamics (PK/PD) principles to enhance therapeutic efficacy. Post-treatment evaluation showed marked improvement in the patient's condition, with lesions exhibiting partial absorption. |
| format | Article |
| id | doaj-art-52a3d81374734c919eca301bca622549 |
| institution | OA Journals |
| issn | 2214-2509 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj-art-52a3d81374734c919eca301bca6225492025-08-20T02:05:19ZengElsevierIDCases2214-25092025-01-0140e0218810.1016/j.idcr.2025.e02188Therapeutic role of fluconazole in immunocompetent patients with pulmonary cryptococcosis: A case reportHuimin Yu0Shuang Hua1Qifei Sha2Tang Tang3Yuzhu Cao4Department of Clinical Pharmacy, Jinling Hospital Affiliated to Nanjing University, Nanjing, Jiangsu 210002, ChinaDepartment of Pharmacy of the Affiliated BenQ Hospital of Nanjing Medical University, 210019, ChinaDepartment of Pharmacy, Anhui Medical College, Hefei, Anhui 230001, ChinaClinical Pharmacy of Shanghai Fourth People’s Hospital affiliated Tongji University, 200434, China; Corresponding authors.Department of Pharmacy, Anhui Medical College, Hefei, Anhui 230001, China; Corresponding authors.The present investigation examines the potential for customized treatment of pulmonary cryptococcosis using fluconazole in an immunocompetent individual. Therapeutic drug monitoring (TDM) was utilized throughout treatment to assess fluconazole levels. Research indicated that the MIC90 for cryptococcus in China is around 8 mg/L. We evaluated the area under the curve (AUC) relative to the minimal inhibitory concentration (MIC), focusing on the AUC from 0 to 24 h (AUC0–24 h/MIC). Fluconazole's dosage was adjusted according to pharmacokinetics/pharmacodynamics (PK/PD) principles to enhance therapeutic efficacy. Post-treatment evaluation showed marked improvement in the patient's condition, with lesions exhibiting partial absorption.http://www.sciencedirect.com/science/article/pii/S2214250925000435Pulmonary cryptococcosisFluconazoleTherapeutic drug monitoringMIC90PK/PD |
| spellingShingle | Huimin Yu Shuang Hua Qifei Sha Tang Tang Yuzhu Cao Therapeutic role of fluconazole in immunocompetent patients with pulmonary cryptococcosis: A case report IDCases Pulmonary cryptococcosis Fluconazole Therapeutic drug monitoring MIC90 PK/PD |
| title | Therapeutic role of fluconazole in immunocompetent patients with pulmonary cryptococcosis: A case report |
| title_full | Therapeutic role of fluconazole in immunocompetent patients with pulmonary cryptococcosis: A case report |
| title_fullStr | Therapeutic role of fluconazole in immunocompetent patients with pulmonary cryptococcosis: A case report |
| title_full_unstemmed | Therapeutic role of fluconazole in immunocompetent patients with pulmonary cryptococcosis: A case report |
| title_short | Therapeutic role of fluconazole in immunocompetent patients with pulmonary cryptococcosis: A case report |
| title_sort | therapeutic role of fluconazole in immunocompetent patients with pulmonary cryptococcosis a case report |
| topic | Pulmonary cryptococcosis Fluconazole Therapeutic drug monitoring MIC90 PK/PD |
| url | http://www.sciencedirect.com/science/article/pii/S2214250925000435 |
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