Increasing seated reaction forces with lower body negative pressure
Abstract This study evaluates ground reaction forces and cardiovascular responses during seated lower body negative pressure (LBNP). Ten healthy subjects were exposed to randomized LBNP levels (−10 to −40 mmHg) while seated in a sealed chamber. Gluteal, foot, and total reaction forces, along with he...
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Nature Portfolio
2025-08-01
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| Series: | npj Microgravity |
| Online Access: | https://doi.org/10.1038/s41526-025-00512-w |
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| author | Suhas Rao Velichala Jonathan Kim Alan R. Hargens |
| author_facet | Suhas Rao Velichala Jonathan Kim Alan R. Hargens |
| author_sort | Suhas Rao Velichala |
| collection | DOAJ |
| description | Abstract This study evaluates ground reaction forces and cardiovascular responses during seated lower body negative pressure (LBNP). Ten healthy subjects were exposed to randomized LBNP levels (−10 to −40 mmHg) while seated in a sealed chamber. Gluteal, foot, and total reaction forces, along with heart rate and blood pressure, were measured at each level. Reaction forces increased significantly with rising LBNP (P < 0.05), exceeding baseline at 10 mmHg and doubling by 30 mmHg. Cardiovascular parameters remained stable, indicating no acute hemodynamic risk. Force generation was dependent on LBNP amplitude and waist cross-sectional area. These findings suggest that seated LBNP is a safe and effective method to simulate Earth-like seated posture in microgravity, offering a promising countermeasure to mitigate musculoskeletal deconditioning and support gravitational adaptation during long-duration spaceflight. |
| format | Article |
| id | doaj-art-52a348e16433402aaa36d8e2a55f9d8f |
| institution | Kabale University |
| issn | 2373-8065 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Microgravity |
| spelling | doaj-art-52a348e16433402aaa36d8e2a55f9d8f2025-08-20T04:03:06ZengNature Portfolionpj Microgravity2373-80652025-08-011111510.1038/s41526-025-00512-wIncreasing seated reaction forces with lower body negative pressureSuhas Rao Velichala0Jonathan Kim1Alan R. Hargens2Department of Orthopaedic Surgery, University of California, San DiegoWestern University of Health SciencesDepartment of Orthopaedic Surgery, University of California, San DiegoAbstract This study evaluates ground reaction forces and cardiovascular responses during seated lower body negative pressure (LBNP). Ten healthy subjects were exposed to randomized LBNP levels (−10 to −40 mmHg) while seated in a sealed chamber. Gluteal, foot, and total reaction forces, along with heart rate and blood pressure, were measured at each level. Reaction forces increased significantly with rising LBNP (P < 0.05), exceeding baseline at 10 mmHg and doubling by 30 mmHg. Cardiovascular parameters remained stable, indicating no acute hemodynamic risk. Force generation was dependent on LBNP amplitude and waist cross-sectional area. These findings suggest that seated LBNP is a safe and effective method to simulate Earth-like seated posture in microgravity, offering a promising countermeasure to mitigate musculoskeletal deconditioning and support gravitational adaptation during long-duration spaceflight.https://doi.org/10.1038/s41526-025-00512-w |
| spellingShingle | Suhas Rao Velichala Jonathan Kim Alan R. Hargens Increasing seated reaction forces with lower body negative pressure npj Microgravity |
| title | Increasing seated reaction forces with lower body negative pressure |
| title_full | Increasing seated reaction forces with lower body negative pressure |
| title_fullStr | Increasing seated reaction forces with lower body negative pressure |
| title_full_unstemmed | Increasing seated reaction forces with lower body negative pressure |
| title_short | Increasing seated reaction forces with lower body negative pressure |
| title_sort | increasing seated reaction forces with lower body negative pressure |
| url | https://doi.org/10.1038/s41526-025-00512-w |
| work_keys_str_mv | AT suhasraovelichala increasingseatedreactionforceswithlowerbodynegativepressure AT jonathankim increasingseatedreactionforceswithlowerbodynegativepressure AT alanrhargens increasingseatedreactionforceswithlowerbodynegativepressure |