Initiation and Regulation of Complement during Hemolytic Transfusion Reactions
Hemolytic transfusion reactions represent one of the most common causes of transfusion-related mortality. Although many factors influence hemolytic transfusion reactions, complement activation represents one of the most common features associated with fatality. In this paper we will focus on the rol...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/307093 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850226110809243648 |
|---|---|
| author | Sean R. Stowell Anne M. Winkler Cheryl L. Maier C. Maridith Arthur Nicole H. Smith Kathryn R. Girard-Pierce Richard D. Cummings James C. Zimring Jeanne E. Hendrickson |
| author_facet | Sean R. Stowell Anne M. Winkler Cheryl L. Maier C. Maridith Arthur Nicole H. Smith Kathryn R. Girard-Pierce Richard D. Cummings James C. Zimring Jeanne E. Hendrickson |
| author_sort | Sean R. Stowell |
| collection | DOAJ |
| description | Hemolytic transfusion reactions represent one of the most common causes of transfusion-related mortality. Although many factors influence hemolytic transfusion reactions, complement activation represents one of the most common features associated with fatality. In this paper we will focus on the role of complement in initiating and regulating hemolytic transfusion reactions and will discuss potential strategies aimed at mitigating or favorably modulating complement during incompatible red blood cell transfusions. |
| format | Article |
| id | doaj-art-52a1fa4d1ade4bd7a34371354637a5da |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-52a1fa4d1ade4bd7a34371354637a5da2025-08-20T02:05:10ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/307093307093Initiation and Regulation of Complement during Hemolytic Transfusion ReactionsSean R. Stowell0Anne M. Winkler1Cheryl L. Maier2C. Maridith Arthur3Nicole H. Smith4Kathryn R. Girard-Pierce5Richard D. Cummings6James C. Zimring7Jeanne E. Hendrickson8Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USADepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USADepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USADepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USADepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA 30322, USADepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USADepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USAPuget Sound Blood Center Research Institute, Seattle, WA 98102, USADepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USAHemolytic transfusion reactions represent one of the most common causes of transfusion-related mortality. Although many factors influence hemolytic transfusion reactions, complement activation represents one of the most common features associated with fatality. In this paper we will focus on the role of complement in initiating and regulating hemolytic transfusion reactions and will discuss potential strategies aimed at mitigating or favorably modulating complement during incompatible red blood cell transfusions.http://dx.doi.org/10.1155/2012/307093 |
| spellingShingle | Sean R. Stowell Anne M. Winkler Cheryl L. Maier C. Maridith Arthur Nicole H. Smith Kathryn R. Girard-Pierce Richard D. Cummings James C. Zimring Jeanne E. Hendrickson Initiation and Regulation of Complement during Hemolytic Transfusion Reactions Clinical and Developmental Immunology |
| title | Initiation and Regulation of Complement during Hemolytic Transfusion Reactions |
| title_full | Initiation and Regulation of Complement during Hemolytic Transfusion Reactions |
| title_fullStr | Initiation and Regulation of Complement during Hemolytic Transfusion Reactions |
| title_full_unstemmed | Initiation and Regulation of Complement during Hemolytic Transfusion Reactions |
| title_short | Initiation and Regulation of Complement during Hemolytic Transfusion Reactions |
| title_sort | initiation and regulation of complement during hemolytic transfusion reactions |
| url | http://dx.doi.org/10.1155/2012/307093 |
| work_keys_str_mv | AT seanrstowell initiationandregulationofcomplementduringhemolytictransfusionreactions AT annemwinkler initiationandregulationofcomplementduringhemolytictransfusionreactions AT cheryllmaier initiationandregulationofcomplementduringhemolytictransfusionreactions AT cmariditharthur initiationandregulationofcomplementduringhemolytictransfusionreactions AT nicolehsmith initiationandregulationofcomplementduringhemolytictransfusionreactions AT kathrynrgirardpierce initiationandregulationofcomplementduringhemolytictransfusionreactions AT richarddcummings initiationandregulationofcomplementduringhemolytictransfusionreactions AT jamesczimring initiationandregulationofcomplementduringhemolytictransfusionreactions AT jeanneehendrickson initiationandregulationofcomplementduringhemolytictransfusionreactions |