Bioinspired 3D hydrogel scaffold to mimic tumor microenvironment for investigating into the anoikis resistance mechanisms in colorectal cancer

Bioinspired 3D hydrogel scaffold to mimic tumor microenvironment for investigating into the anoikis resistance mechanisms in colorectal cancer

Anoikis resistance constitutes a critical pathophysiological mechanism driving metastatic progression in colorectal cancer. While in vitro models are essential for mechanistic studies, conventional 2D cultures inadequately replicate tumor microenvironment (TME) complexity. In this study, we develope...

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Bibliographic Details
Main Authors: Jia Weng, Shicheng Li, Jiacheng Weng, Yan Wang, Bincan Deng, Mengxian Yao, Hongke Hao, Xia Huang, Lei Gan, Bo Chen, Xuan Xue, Zhigang Chen
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
Subjects:
Biomimetic hydrogels
Anoikis resistance
3D cell scaffold
Bioinformatic and radiomics analysis
Colorectal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425006313
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