Systemic inflammation-based Glasgow Prognostic Score as a prognostic indicator in chronic heart failure
Background: The Glasgow Prognostic Score (GPS), based on C-reactive protein and serum albumin concentrations provides useful prognostic information for patients with cancer or acute decompensated heart failure (HF). Herein, we aimed to evaluate the relationship between the GPS and long-term prognosi...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906725000636 |
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| author | Shigeto Namiuchi Kotaro Nochioka Ryoichi Ushigome Shinichiro Sunamura Atsushi Tanita Tsuyoshi Ogata Kazuki Noda Toru Takii Hiroaki Shimokawa Satoshi Yasuda |
| author_facet | Shigeto Namiuchi Kotaro Nochioka Ryoichi Ushigome Shinichiro Sunamura Atsushi Tanita Tsuyoshi Ogata Kazuki Noda Toru Takii Hiroaki Shimokawa Satoshi Yasuda |
| author_sort | Shigeto Namiuchi |
| collection | DOAJ |
| description | Background: The Glasgow Prognostic Score (GPS), based on C-reactive protein and serum albumin concentrations provides useful prognostic information for patients with cancer or acute decompensated heart failure (HF). Herein, we aimed to evaluate the relationship between the GPS and long-term prognosis in patients with chronic HF. Methods: In this large multicentre prospective observational study, part of the Chronic Heart Failure Analysis and Registry in the Tohoku District-2 (CHART-2) Study, we analysed the relationship between mortality and the GPS in 6,480 patients with chronic HF (mean age, 68 ± 13 years; 69 % male). Patients with elevated C-reactive protein levels (>1.0 mg/dL) and hypoalbuminaemia (<3.5 g/dL) received a GPS of 2; those with either received a GPS of 1, and those with neither received a GPS of 0. Results: During median follow-up of 9.62 years, 2,564 patients (39.6 %) died. Increased GPS was associated with a significantly higher mortality risk in Kaplan–Meier analysis (log-rank P < 0.0001). This trend was consistent across sex, age, New York Heart Association class, HF stage and type, and cancer history. Adjusted Cox proportional hazards analysis showed the following hazard ratios for all-cause death, relative to a GPS of 0, 1.27 (95 % confidence interval, 1.13–1.44; P < 0.0001) for a GPS of 1 and 1.83 (95 % confidence interval, 1.45–2.32; P < 0.0001) for a GPS of 2. This increased risk was independent of B-type natriuretic peptide levels. Conclusions: The GPS, which reflects systemic inflammation status, is a useful predictor of long-term prognosis in patients with chronic HF. |
| format | Article |
| id | doaj-art-529405720c9e418f9012b6b1a21fa4b2 |
| institution | Kabale University |
| issn | 2352-9067 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj-art-529405720c9e418f9012b6b1a21fa4b22025-08-20T03:49:46ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672025-06-015810166010.1016/j.ijcha.2025.101660Systemic inflammation-based Glasgow Prognostic Score as a prognostic indicator in chronic heart failureShigeto Namiuchi0Kotaro Nochioka1Ryoichi Ushigome2Shinichiro Sunamura3Atsushi Tanita4Tsuyoshi Ogata5Kazuki Noda6Toru Takii7Hiroaki Shimokawa8Satoshi Yasuda9Department of Cardiology, Sendai City Medical Center, Sendai Open Hospital, Sendai, Japan; Corresponding author at: At: Shigeto Namiuchi, Department of Cardiology, Sendai City Medical Center, Sendai Open Hospital 5-22-1 Tsurugaya, Miyagino-ku, Sendai 983-0824, Japan.Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanUshigome Clinic, Sendai, JapanDepartment of Cardiology, Sendai City Medical Center, Sendai Open Hospital, Sendai, JapanDepartment of Cardiology, Sendai City Medical Center, Sendai Open Hospital, Sendai, JapanDepartment of Cardiology, Sendai City Medical Center, Sendai Open Hospital, Sendai, JapanDepartment of Cardiology, Sendai City Medical Center, Sendai Open Hospital, Sendai, JapanDepartment of Cardiology, Sendai City Medical Center, Sendai Open Hospital, Sendai, JapanInternational University of Health and Welfare, Narita, JapanDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanBackground: The Glasgow Prognostic Score (GPS), based on C-reactive protein and serum albumin concentrations provides useful prognostic information for patients with cancer or acute decompensated heart failure (HF). Herein, we aimed to evaluate the relationship between the GPS and long-term prognosis in patients with chronic HF. Methods: In this large multicentre prospective observational study, part of the Chronic Heart Failure Analysis and Registry in the Tohoku District-2 (CHART-2) Study, we analysed the relationship between mortality and the GPS in 6,480 patients with chronic HF (mean age, 68 ± 13 years; 69 % male). Patients with elevated C-reactive protein levels (>1.0 mg/dL) and hypoalbuminaemia (<3.5 g/dL) received a GPS of 2; those with either received a GPS of 1, and those with neither received a GPS of 0. Results: During median follow-up of 9.62 years, 2,564 patients (39.6 %) died. Increased GPS was associated with a significantly higher mortality risk in Kaplan–Meier analysis (log-rank P < 0.0001). This trend was consistent across sex, age, New York Heart Association class, HF stage and type, and cancer history. Adjusted Cox proportional hazards analysis showed the following hazard ratios for all-cause death, relative to a GPS of 0, 1.27 (95 % confidence interval, 1.13–1.44; P < 0.0001) for a GPS of 1 and 1.83 (95 % confidence interval, 1.45–2.32; P < 0.0001) for a GPS of 2. This increased risk was independent of B-type natriuretic peptide levels. Conclusions: The GPS, which reflects systemic inflammation status, is a useful predictor of long-term prognosis in patients with chronic HF.http://www.sciencedirect.com/science/article/pii/S2352906725000636AlbuminC-reactive proteinChronic heart failureGlasgow Prognostic ScoreMortality |
| spellingShingle | Shigeto Namiuchi Kotaro Nochioka Ryoichi Ushigome Shinichiro Sunamura Atsushi Tanita Tsuyoshi Ogata Kazuki Noda Toru Takii Hiroaki Shimokawa Satoshi Yasuda Systemic inflammation-based Glasgow Prognostic Score as a prognostic indicator in chronic heart failure International Journal of Cardiology: Heart & Vasculature Albumin C-reactive protein Chronic heart failure Glasgow Prognostic Score Mortality |
| title | Systemic inflammation-based Glasgow Prognostic Score as a prognostic indicator in chronic heart failure |
| title_full | Systemic inflammation-based Glasgow Prognostic Score as a prognostic indicator in chronic heart failure |
| title_fullStr | Systemic inflammation-based Glasgow Prognostic Score as a prognostic indicator in chronic heart failure |
| title_full_unstemmed | Systemic inflammation-based Glasgow Prognostic Score as a prognostic indicator in chronic heart failure |
| title_short | Systemic inflammation-based Glasgow Prognostic Score as a prognostic indicator in chronic heart failure |
| title_sort | systemic inflammation based glasgow prognostic score as a prognostic indicator in chronic heart failure |
| topic | Albumin C-reactive protein Chronic heart failure Glasgow Prognostic Score Mortality |
| url | http://www.sciencedirect.com/science/article/pii/S2352906725000636 |
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