The Coronavirus SARS-Cov-2: the Complexity of Infection Pathogenesis, the Search of Vaccines and Possible Future Pandemics
Relevance. The vaccine against the SARS-Cov-2 coronavirus is considered as the most promising approach to curb (tame) a current pandemic and prevent new one. Among difficulties in vaccine creating is a right choice of immunodominant antigens providing the effectiveness and safety of vaccines. Aim is...
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2020-07-01
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| Series: | Эпидемиология и вакцинопрофилактика |
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| Online Access: | https://www.epidemvac.ru/jour/article/view/1025 |
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| author | E. P. Kharchenko |
| author_facet | E. P. Kharchenko |
| author_sort | E. P. Kharchenko |
| collection | DOAJ |
| description | Relevance. The vaccine against the SARS-Cov-2 coronavirus is considered as the most promising approach to curb (tame) a current pandemic and prevent new one. Among difficulties in vaccine creating is a right choice of immunodominant antigens providing the effectiveness and safety of vaccines. Aim is to show the usefulness of application of the global immune epitope continuum protein relationship concept in the search of vaccines against SARS-Cov-2 and discuss the possible nature of future pandemics. Materials and method. For the computer analysis of peptide (immune epitope) relationship amongst the SARS-Cov-2 structural proteins, human proteins and proteins of other viruses, the search of homologous sequences was made. All protein sequences sequences were used from databases available on the INTERNET. Results. In the SARS-Cov-2 structural proteins, especially in S-protein, there are a large number of peptide sequences homologous to human and viral proteins that may be the cause of autoimmune complications and/or heterologous immunity. Conclusion: The concept of the global immune epitope continuum of protein relationship is of value in the search of immune epitopes for the vaccines against SARS-Cov-2 and allows us to predict the possible risks in vaccines. The coronavirus breaks and pandemics may be more often than the influenza pandemics. |
| format | Article |
| id | doaj-art-528beff9a2e54b3e8886f88e25fa4715 |
| institution | Kabale University |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| publishDate | 2020-07-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj-art-528beff9a2e54b3e8886f88e25fa47152025-08-20T03:34:43ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942020-07-0119342010.31631/2073-3046-2020-19-3-4-20648The Coronavirus SARS-Cov-2: the Complexity of Infection Pathogenesis, the Search of Vaccines and Possible Future PandemicsE. P. Kharchenko0Sechenov Institute of Evolutionary Physiology and BiochemistryRelevance. The vaccine against the SARS-Cov-2 coronavirus is considered as the most promising approach to curb (tame) a current pandemic and prevent new one. Among difficulties in vaccine creating is a right choice of immunodominant antigens providing the effectiveness and safety of vaccines. Aim is to show the usefulness of application of the global immune epitope continuum protein relationship concept in the search of vaccines against SARS-Cov-2 and discuss the possible nature of future pandemics. Materials and method. For the computer analysis of peptide (immune epitope) relationship amongst the SARS-Cov-2 structural proteins, human proteins and proteins of other viruses, the search of homologous sequences was made. All protein sequences sequences were used from databases available on the INTERNET. Results. In the SARS-Cov-2 structural proteins, especially in S-protein, there are a large number of peptide sequences homologous to human and viral proteins that may be the cause of autoimmune complications and/or heterologous immunity. Conclusion: The concept of the global immune epitope continuum of protein relationship is of value in the search of immune epitopes for the vaccines against SARS-Cov-2 and allows us to predict the possible risks in vaccines. The coronavirus breaks and pandemics may be more often than the influenza pandemics.https://www.epidemvac.ru/jour/article/view/1025sars-cov-2cov-2s-proteinvaccinepandemic |
| spellingShingle | E. P. Kharchenko The Coronavirus SARS-Cov-2: the Complexity of Infection Pathogenesis, the Search of Vaccines and Possible Future Pandemics Эпидемиология и вакцинопрофилактика sars-cov-2 cov-2 s-protein vaccine pandemic |
| title | The Coronavirus SARS-Cov-2: the Complexity of Infection Pathogenesis, the Search of Vaccines and Possible Future Pandemics |
| title_full | The Coronavirus SARS-Cov-2: the Complexity of Infection Pathogenesis, the Search of Vaccines and Possible Future Pandemics |
| title_fullStr | The Coronavirus SARS-Cov-2: the Complexity of Infection Pathogenesis, the Search of Vaccines and Possible Future Pandemics |
| title_full_unstemmed | The Coronavirus SARS-Cov-2: the Complexity of Infection Pathogenesis, the Search of Vaccines and Possible Future Pandemics |
| title_short | The Coronavirus SARS-Cov-2: the Complexity of Infection Pathogenesis, the Search of Vaccines and Possible Future Pandemics |
| title_sort | coronavirus sars cov 2 the complexity of infection pathogenesis the search of vaccines and possible future pandemics |
| topic | sars-cov-2 cov-2 s-protein vaccine pandemic |
| url | https://www.epidemvac.ru/jour/article/view/1025 |
| work_keys_str_mv | AT epkharchenko thecoronavirussarscov2thecomplexityofinfectionpathogenesisthesearchofvaccinesandpossiblefuturepandemics AT epkharchenko coronavirussarscov2thecomplexityofinfectionpathogenesisthesearchofvaccinesandpossiblefuturepandemics |