Regional heterogeneity of the blood-brain barrier

Regional heterogeneity of the blood-brain barrier

Abstract The blood-brain barrier (BBB), formed by specialized endothelial cells (ECs), regulates the extracellular composition of the central nervous system (CNS). Little is known about whether there are regional specializations of the BBB that may control the function of specific neural circuits. W...

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Main Authors: Marie Blanchette, Kaja Bajc, Benjamin D. Gastfriend, Caterina P. Profaci, Nadine Ruderisch, Cayce E. Dorrier, Guo Zhong, Raquel Cuevas-Diaz Duran, Sean S. Harvey, Iris H. Garcia-Pak, Lucija Pintarić, Manon Leclerc, Louise Reveret, Vincent Émond, Annette Wang, Deepti Pant, Linus T. Tsai, Frédéric Calon, Nina Isoherranen, Sean P. Palecek, Eric V. Shusta, Jiaqian Wu, Richard Daneman
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61841-8
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