Cutaneous Metastases—Histological Particularities of Multifaceted Entities

Cutaneous metastases from internal organ cancers are diagnosed in approximately 0.2% of skin biopsies. This diagnosis can be the first sign of a previously undiagnosed malignancy with an internal organ origin. We conducted a retrospective study that included all cases of cutaneous metastases diagnos...

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Main Authors: Andreea Cătălina Tinca, Bianca Andreea Lazar, Andreea Raluca Cozac-Szőke, Georgian Nicolae Radu, Simina Petra Simion, Diana Maria Chiorean, Irina Bianca Kosovski, Adrian Horațiu Sabău, Raluca Niculescu, Iuliu Gabriel Cocuz, Raluca-Diana Hagău, Emoke Andrea Szasz, Sabin Gligore Turdean, Ovidiu Simion Cotoi
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Dermatopathology
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Online Access:https://www.mdpi.com/2296-3529/12/2/14
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author Andreea Cătălina Tinca
Bianca Andreea Lazar
Andreea Raluca Cozac-Szőke
Georgian Nicolae Radu
Simina Petra Simion
Diana Maria Chiorean
Irina Bianca Kosovski
Adrian Horațiu Sabău
Raluca Niculescu
Iuliu Gabriel Cocuz
Raluca-Diana Hagău
Emoke Andrea Szasz
Sabin Gligore Turdean
Ovidiu Simion Cotoi
author_facet Andreea Cătălina Tinca
Bianca Andreea Lazar
Andreea Raluca Cozac-Szőke
Georgian Nicolae Radu
Simina Petra Simion
Diana Maria Chiorean
Irina Bianca Kosovski
Adrian Horațiu Sabău
Raluca Niculescu
Iuliu Gabriel Cocuz
Raluca-Diana Hagău
Emoke Andrea Szasz
Sabin Gligore Turdean
Ovidiu Simion Cotoi
author_sort Andreea Cătălina Tinca
collection DOAJ
description Cutaneous metastases from internal organ cancers are diagnosed in approximately 0.2% of skin biopsies. This diagnosis can be the first sign of a previously undiagnosed malignancy with an internal organ origin. We conducted a retrospective study that included all cases of cutaneous metastases diagnosed in our hospital. A total of 25 patients were identified (14 females and 11 males). The average age of the patients included was 62.3. The most common primary cancer site was the lung for male patients, while for female patients it was the breast. In seven of our cases, cutaneous metastases were the first sign of an internal organ cancer. Common sites for cutaneous metastases in our study involved the anterior thoracic wall, the abdomen, and the scalp. Our study aims to highlight the importance of recognizing the histopathology of metastatic tumors and differentiating them from primary skin neoplasms. Immunohistochemistry is a mandatory tool for differential diagnosis in all cases, especially for patients who do not have a history of neoplasia.
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institution Kabale University
issn 2296-3529
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publishDate 2025-04-01
publisher MDPI AG
record_format Article
series Dermatopathology
spelling doaj-art-5287590a71024c209fa4822e174200452025-08-20T03:24:39ZengMDPI AGDermatopathology2296-35292025-04-011221410.3390/dermatopathology12020014Cutaneous Metastases—Histological Particularities of Multifaceted EntitiesAndreea Cătălina Tinca0Bianca Andreea Lazar1Andreea Raluca Cozac-Szőke2Georgian Nicolae Radu3Simina Petra Simion4Diana Maria Chiorean5Irina Bianca Kosovski6Adrian Horațiu Sabău7Raluca Niculescu8Iuliu Gabriel Cocuz9Raluca-Diana Hagău10Emoke Andrea Szasz11Sabin Gligore Turdean12Ovidiu Simion Cotoi13Pathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540142 Târgu-Mureș, RomaniaPathology Department, Mureș Clinical County Hospital, 540003 Târgu Mureș, RomaniaPathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540142 Târgu-Mureș, RomaniaPathology Department, Mureș Clinical County Hospital, 540003 Târgu Mureș, RomaniaPathology Department, Mureș Clinical County Hospital, 540003 Târgu Mureș, RomaniaPathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540142 Târgu-Mureș, RomaniaPathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540142 Târgu-Mureș, RomaniaPathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540142 Târgu-Mureș, RomaniaPathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540142 Târgu-Mureș, RomaniaPathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540142 Târgu-Mureș, RomaniaPathology Department, Mureș Clinical County Hospital, 540003 Târgu Mureș, RomaniaPathology Department, Mureș Clinical County Hospital, 540003 Târgu Mureș, RomaniaPathology Department, Mureș Clinical County Hospital, 540003 Târgu Mureș, RomaniaPathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540142 Târgu-Mureș, RomaniaCutaneous metastases from internal organ cancers are diagnosed in approximately 0.2% of skin biopsies. This diagnosis can be the first sign of a previously undiagnosed malignancy with an internal organ origin. We conducted a retrospective study that included all cases of cutaneous metastases diagnosed in our hospital. A total of 25 patients were identified (14 females and 11 males). The average age of the patients included was 62.3. The most common primary cancer site was the lung for male patients, while for female patients it was the breast. In seven of our cases, cutaneous metastases were the first sign of an internal organ cancer. Common sites for cutaneous metastases in our study involved the anterior thoracic wall, the abdomen, and the scalp. Our study aims to highlight the importance of recognizing the histopathology of metastatic tumors and differentiating them from primary skin neoplasms. Immunohistochemistry is a mandatory tool for differential diagnosis in all cases, especially for patients who do not have a history of neoplasia.https://www.mdpi.com/2296-3529/12/2/14cutaneous metastasescancersimmunohistochemistry
spellingShingle Andreea Cătălina Tinca
Bianca Andreea Lazar
Andreea Raluca Cozac-Szőke
Georgian Nicolae Radu
Simina Petra Simion
Diana Maria Chiorean
Irina Bianca Kosovski
Adrian Horațiu Sabău
Raluca Niculescu
Iuliu Gabriel Cocuz
Raluca-Diana Hagău
Emoke Andrea Szasz
Sabin Gligore Turdean
Ovidiu Simion Cotoi
Cutaneous Metastases—Histological Particularities of Multifaceted Entities
Dermatopathology
cutaneous metastases
cancers
immunohistochemistry
title Cutaneous Metastases—Histological Particularities of Multifaceted Entities
title_full Cutaneous Metastases—Histological Particularities of Multifaceted Entities
title_fullStr Cutaneous Metastases—Histological Particularities of Multifaceted Entities
title_full_unstemmed Cutaneous Metastases—Histological Particularities of Multifaceted Entities
title_short Cutaneous Metastases—Histological Particularities of Multifaceted Entities
title_sort cutaneous metastases histological particularities of multifaceted entities
topic cutaneous metastases
cancers
immunohistochemistry
url https://www.mdpi.com/2296-3529/12/2/14
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